Strong Antimicrobial Effects of Xanthohumol and Beta-Acids from Hops against Clostridioides difficile Infection In Vivo

( ) is an important causative pathogen of nosocomial gastrointestinal infections in humans with an increasing incidence, morbidity, and mortality. The available treatment options against this pathogen are limited. The standard antibiotics are expensive, can promote emerging resistance, and the recur...

Full description

Saved in:
Bibliographic Details
Published in:Antibiotics (Basel) 2021-04, Vol.10 (4), p.392
Main Authors: Sleha, Radek, Radochova, Vera, Mikyska, Alexander, Houska, Milan, Bolehovska, Radka, Janovska, Sylva, Pejchal, Jaroslav, Muckova, Lubica, Cermak, Pavel, Bostik, Pavel
Format: Article
Language:English
Subjects:
Acids
Animals
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
C. difficile
Diarrhea
Edema
Experiments
Feces
Hops
Hospitals
infection
Infections
Inflammation
Inflammatory bowel disease
Intestine
Large intestine
Morbidity
Neutrophils
Nosocomial infection
Pathogens
Physiology
rat model
Xanthohumol
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:( ) is an important causative pathogen of nosocomial gastrointestinal infections in humans with an increasing incidence, morbidity, and mortality. The available treatment options against this pathogen are limited. The standard antibiotics are expensive, can promote emerging resistance, and the recurrence rate of the infection is high. Therefore, there is an urgent need for new approaches to meet these challenges. One of the possible treatment alternatives is to use compounds available in commonly used plants. In this study, purified extracts isolated from hops-alpha and beta acids and xanthohumol-were tested in vivo for their inhibitory effect against . A rat model of the peroral intestinal infection by has been developed. The results show that both xanthohumol and beta acids from hops exert a notable antimicrobial effect in the infection. The xanthohumol application showed the most pronounced antimicrobial effect together with an improvement of local inflammatory signs in the large intestine. Thus, the hops compounds represent promising antimicrobial agents for the treatment of intestinal infections caused by .
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics10040392