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Strong Antimicrobial Effects of Xanthohumol and Beta-Acids from Hops against Clostridioides difficile Infection In Vivo
( ) is an important causative pathogen of nosocomial gastrointestinal infections in humans with an increasing incidence, morbidity, and mortality. The available treatment options against this pathogen are limited. The standard antibiotics are expensive, can promote emerging resistance, and the recur...
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| Published in: | Antibiotics (Basel) 2021-04, Vol.10 (4), p.392 |
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| Main Authors: | , , , , , , , , , |
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| container_issue | 4 |
| container_start_page | 392 |
| container_title | Antibiotics (Basel) |
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| creator | Sleha, Radek Radochova, Vera Mikyska, Alexander Houska, Milan Bolehovska, Radka Janovska, Sylva Pejchal, Jaroslav Muckova, Lubica Cermak, Pavel Bostik, Pavel |
| description | (
)
is an important causative pathogen of nosocomial gastrointestinal infections in humans with an increasing incidence, morbidity, and mortality. The available treatment options against this pathogen are limited. The standard antibiotics are expensive, can promote emerging resistance, and the recurrence rate of the infection is high. Therefore, there is an urgent need for new approaches to meet these challenges. One of the possible treatment alternatives is to use compounds available in commonly used plants. In this study, purified extracts isolated from hops-alpha and beta acids and xanthohumol-were tested in vivo for their inhibitory effect against
. A rat model of the peroral intestinal infection by
has been developed. The results show that both xanthohumol and beta acids from hops exert a notable antimicrobial effect in the
infection. The xanthohumol application showed the most pronounced antimicrobial effect together with an improvement of local inflammatory signs in the large intestine. Thus, the hops compounds represent promising antimicrobial agents for the treatment of intestinal infections caused by
. |
| doi_str_mv | 10.3390/antibiotics10040392 |
| format | article |
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is an important causative pathogen of nosocomial gastrointestinal infections in humans with an increasing incidence, morbidity, and mortality. The available treatment options against this pathogen are limited. The standard antibiotics are expensive, can promote emerging resistance, and the recurrence rate of the infection is high. Therefore, there is an urgent need for new approaches to meet these challenges. One of the possible treatment alternatives is to use compounds available in commonly used plants. In this study, purified extracts isolated from hops-alpha and beta acids and xanthohumol-were tested in vivo for their inhibitory effect against
. A rat model of the peroral intestinal infection by
has been developed. The results show that both xanthohumol and beta acids from hops exert a notable antimicrobial effect in the
infection. The xanthohumol application showed the most pronounced antimicrobial effect together with an improvement of local inflammatory signs in the large intestine. Thus, the hops compounds represent promising antimicrobial agents for the treatment of intestinal infections caused by
.</description><identifier>ISSN: 2079-6382</identifier><identifier>EISSN: 2079-6382</identifier><identifier>DOI: 10.3390/antibiotics10040392</identifier><identifier>PMID: 33917416</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acids ; Animals ; Antibiotics ; Antiinfectives and antibacterials ; Antimicrobial agents ; Bacteria ; C. difficile ; Diarrhea ; Edema ; Experiments ; Feces ; Hops ; Hospitals ; infection ; Infections ; Inflammation ; Inflammatory bowel disease ; Intestine ; Large intestine ; Morbidity ; Neutrophils ; Nosocomial infection ; Pathogens ; Physiology ; rat model ; Xanthohumol</subject><ispartof>Antibiotics (Basel), 2021-04, Vol.10 (4), p.392</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-f9ae7fdcfc5d01284153141c6854e7bd5d827aeddfbfd3cf30abdad4e9272a213</citedby><cites>FETCH-LOGICAL-c499t-f9ae7fdcfc5d01284153141c6854e7bd5d827aeddfbfd3cf30abdad4e9272a213</cites><orcidid>0000-0001-7359-9147 ; 0000-0003-2228-7922 ; 0000-0001-6693-6061 ; 0000-0001-7025-1436 ; 0000-0003-2384-8875 ; 0000-0003-2691-6458 ; 0000-0002-1477-5451</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2528292183/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2528292183?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33917416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sleha, Radek</creatorcontrib><creatorcontrib>Radochova, Vera</creatorcontrib><creatorcontrib>Mikyska, Alexander</creatorcontrib><creatorcontrib>Houska, Milan</creatorcontrib><creatorcontrib>Bolehovska, Radka</creatorcontrib><creatorcontrib>Janovska, Sylva</creatorcontrib><creatorcontrib>Pejchal, Jaroslav</creatorcontrib><creatorcontrib>Muckova, Lubica</creatorcontrib><creatorcontrib>Cermak, Pavel</creatorcontrib><creatorcontrib>Bostik, Pavel</creatorcontrib><title>Strong Antimicrobial Effects of Xanthohumol and Beta-Acids from Hops against Clostridioides difficile Infection In Vivo</title><title>Antibiotics (Basel)</title><addtitle>Antibiotics (Basel)</addtitle><description>(
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is an important causative pathogen of nosocomial gastrointestinal infections in humans with an increasing incidence, morbidity, and mortality. The available treatment options against this pathogen are limited. The standard antibiotics are expensive, can promote emerging resistance, and the recurrence rate of the infection is high. Therefore, there is an urgent need for new approaches to meet these challenges. One of the possible treatment alternatives is to use compounds available in commonly used plants. In this study, purified extracts isolated from hops-alpha and beta acids and xanthohumol-were tested in vivo for their inhibitory effect against
. A rat model of the peroral intestinal infection by
has been developed. The results show that both xanthohumol and beta acids from hops exert a notable antimicrobial effect in the
infection. The xanthohumol application showed the most pronounced antimicrobial effect together with an improvement of local inflammatory signs in the large intestine. Thus, the hops compounds represent promising antimicrobial agents for the treatment of intestinal infections caused by
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)
is an important causative pathogen of nosocomial gastrointestinal infections in humans with an increasing incidence, morbidity, and mortality. The available treatment options against this pathogen are limited. The standard antibiotics are expensive, can promote emerging resistance, and the recurrence rate of the infection is high. Therefore, there is an urgent need for new approaches to meet these challenges. One of the possible treatment alternatives is to use compounds available in commonly used plants. In this study, purified extracts isolated from hops-alpha and beta acids and xanthohumol-were tested in vivo for their inhibitory effect against
. A rat model of the peroral intestinal infection by
has been developed. The results show that both xanthohumol and beta acids from hops exert a notable antimicrobial effect in the
infection. The xanthohumol application showed the most pronounced antimicrobial effect together with an improvement of local inflammatory signs in the large intestine. Thus, the hops compounds represent promising antimicrobial agents for the treatment of intestinal infections caused by
.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33917416</pmid><doi>10.3390/antibiotics10040392</doi><orcidid>https://orcid.org/0000-0001-7359-9147</orcidid><orcidid>https://orcid.org/0000-0003-2228-7922</orcidid><orcidid>https://orcid.org/0000-0001-6693-6061</orcidid><orcidid>https://orcid.org/0000-0001-7025-1436</orcidid><orcidid>https://orcid.org/0000-0003-2384-8875</orcidid><orcidid>https://orcid.org/0000-0003-2691-6458</orcidid><orcidid>https://orcid.org/0000-0002-1477-5451</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Antibiotics (Basel), 2021-04, Vol.10 (4), p.392 |
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| subjects | Acids Animals Antibiotics Antiinfectives and antibacterials Antimicrobial agents Bacteria C. difficile Diarrhea Edema Experiments Feces Hops Hospitals infection Infections Inflammation Inflammatory bowel disease Intestine Large intestine Morbidity Neutrophils Nosocomial infection Pathogens Physiology rat model Xanthohumol |
| title | Strong Antimicrobial Effects of Xanthohumol and Beta-Acids from Hops against Clostridioides difficile Infection In Vivo |
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