Clinical and histological comparison of platelet-rich fibrin versus non-eugenol periodontal dressing in the treatment of gingival hyperpigmentation

Background: The platelet-rich fibrin (PRF) has proven an immense role in angiogenesis and epithelization in a wound healing process. The present study aims to ascertain PRF's beneficial role in wound healing after depigmentation surgery. Materials and Methods: A total of 12 systemically healthy...

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Published in:Journal of Indian Society of Periodontology 2019-07, Vol.23 (4), p.345-350
Main Authors: Dahiya, Ritu, Blaggana, Anshu, Panwar, Vinod, Kumar, Shubham, Kathuria, Abhinav, Malik, Srijna
Format: Article
Language:English
Subjects:
Angiogenesis
Biopsy
Cell division
Comparative analysis
Eugenol
Fibrin
Gingival hyperpigmentation
Hyperpigmentation
Inflammation
Neutrophils
non-eugenol periodontal dressing
Original
Patients
Periodontics
Phenols (Class of compounds)
Pigmentation disorders
platelet-rich fibrin
Platelets
Statistical analysis
Surgery
Toluidine
Wound care
Wound healing
Wounds
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Summary:Background: The platelet-rich fibrin (PRF) has proven an immense role in angiogenesis and epithelization in a wound healing process. The present study aims to ascertain PRF's beneficial role in wound healing after depigmentation surgery. Materials and Methods: A total of 12 systemically healthy controls included were divided into two groups after scalpel depigmentation procedure. PRF was prepared according to Choukroun's standard protocol. Using split-mouth design after depigmentation, one group received PRF membrane, and in second group non-eugenol periodontal dressing was placed. The participants were evaluated for visual analog scale (VAS), healing index (HI) on 3rd and 5th day. Epithelization test using toluidine blue and histological examination employing punch biopsy was done on the 5th day. Results: On statistical scale, VAS, HI, epithelization test, and histological findings were statistically significant in the two study groups. PRF group proved better epithelization test and inflammatory cell infiltration was less in PRF group which confirmed superior wound healing in the group. Conclusion: PRF membrane postdepigmentation provided satisfactory patient comfort and enhanced the wound healing cascade.
ISSN:0972-124X
0975-1580
DOI:10.4103/jisp.jisp_688_18