Comparative genomics of 40 Weissella paramesenteroides strains

• Published in: Frontiers in microbiology 2023-03, Vol.14, p.1128028-1128028
• Main Authors: Wan, Xing, Takala, Timo M, Huynh, Vy A, Ahonen, Susanna L, Paulin, Lars, Björkroth, Johanna, Sironen, Tarja, Kant, Ravi, Saris, Per
• Format: Article
• Language: English
• Subjects: comparative genomics; core genome; heterofermentative bacteria; Microbiology; pangenome analysis; vancomycin resistance; Weissella paramesenteroides
• ISSN: 1664-302X; 1664-302X
• DOI: 10.3389/fmicb.2023.1128028

strains are often detected in spontaneously fermented foods. Because of their abilities to produce lactic acid and functional exopolysaccharides as well as their probiotic traits, spp. improve not only the sensorial properties but also nutritional values of the fermented food products. However, some species have been associated with human and animal diseases. In the era of vast genomic sequencing, new genomic/genome data are becoming available to the public on daily pace. Detailed genomic analyses are due to provide a full understanding of individual species. In this study, the genomes of six strains were sequenced. The genomes of 42 strains were compared to discover their metabolic and functional potentials in food fermentation. Comparative genomics and metabolic pathway reconstructions revealed that is a compact group of heterofermentative bacteria with good capacity of producing secondary metabolites and vitamin Bs. Since the strains rarely harbored plasmid DNA, they did not commonly possess the genes associated with bacteriocin production. All 42 strains were shown to bear gene from the glycopeptide resistance gene cluster vanG. Yet none of the strains carried virulence genes.