Proteomics and metabolomics analyses of camptothecin-producing Aspergillus terreus reveal the integration of PH domain-containing proteins and peptidylprolyl cis/trans isomerase in restoring the camptothecin biosynthesis

Decreasing the camptothecin productivity by fungi with storage and subculturing is the challenge that halts their further implementation to be an industrial platform for camptothecin (CPT) production. The highest differentially abundant proteins were Pleckstrin homology (PH) domain-containing protei...

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Bibliographic Details
Published in:Microbiology spectrum 2023-12, Vol.11 (6), p.e0228123-e0228123
Main Authors: Rady, Amgad M, El-Sayed, Ashraf S A, El-Baz, Ashraf F, Abdel-Fattah, Ghada G, Magdeldin, Sameh, Ahmed, Eman, Osama, Aya, Hassanein, Sameh E, Saed, Hend, Yassin, Marwa
Format: Article
Language:English
Subjects:
Applied and Industrial Microbiology
Aspergillus terreus
camptothecin
metabolomics analysis
proteomics analysis
Research Article
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Summary:Decreasing the camptothecin productivity by fungi with storage and subculturing is the challenge that halts their further implementation to be an industrial platform for camptothecin (CPT) production. The highest differentially abundant proteins were Pleckstrin homology (PH) domain-containing proteins and Peptidyl-prolyl / isomerase that fluctuated with the subculturing of with a remarkable relation to CPT biosynthesis and restored with addition of microbiome.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.02281-23