Association of High Serum Chemerin with Bone Mineral Density Loss and Osteoporotic Fracture in Elderly Chinese Women

Chemerin has been suggested to be a risk factor for osteoporosis; however, its relationship with osteoporotic fracture is poorly understood. Herein, we intend to explore the association between serum chemerin and osteoporotic fracture. A total of 111 elderly women patients diagnosed with osteoporoti...

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Bibliographic Details
Published in:International journal of women's health 2022-01, Vol.14, p.107-118
Main Authors: Jiang, Xi-Yuan, Wang, Qing, Zhang, Ying, Chen, Yong, Wu, Long-Fei
Format: Article
Language:English
Subjects:
Aged
Analysis
Biomarkers
Bone density
chemerin
Chemokines
Chinese medicine
Collagen
elderly women
Enzyme-linked immunosorbent assay
Enzymes
Fractures
Gene expression
Health aspects
Health care
Laboratories
Metabolism
Neomycin
Older people
Original Research
Osteoporosis
osteoporotic fracture
Phosphatase
Phosphatases
Proteins
Regression analysis
risk factor
Risk factors
RNA
Standard deviation
Women
Womens health
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Summary:Chemerin has been suggested to be a risk factor for osteoporosis; however, its relationship with osteoporotic fracture is poorly understood. Herein, we intend to explore the association between serum chemerin and osteoporotic fracture. A total of 111 elderly women patients diagnosed with osteoporotic fracture were selected as the observation group, and 40 healthy subjects were enrolled as controls. Dual-energy X-ray absorptiometry, enzyme-linked immunosorbent assay, electrochemiluminescence immunoassay, and biochemical analysis were separately performed to determine body bone mineral density (BMD), chemerin levels, bone turnover markers, and other parameters. Pearson's correlation analysis was conducted to examine a relationship between chemerin and laboratory parameters. Moreover, the levels of chemokine-like receptor 1 ( ), C-C motif chemokine receptor-like 2 ( ), collagen type I alpha (COLA1), and runt-related transcription factor-2 ( ) were confirmed by quantitative polymerase chain reaction, and the effect of chemerin on osteogenic differentiation of hFOB1.19 cells was indicated by tartrate-resistant acid phosphatase and alkaline phosphatase double staining. A higher level of chemerin was generally detected in patients with osteoporotic fracture compared with those without (
ISSN:1179-1411
1179-1411
DOI:10.2147/IJWH.S337985