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Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and its Implication for Medicine
Oxygen (O ) is essential for human life. Molecular oxygen is vital for the production of adenosine triphosphate (ATP) in human cells. O deficiency leads to a reduction in the energy levels that are required to maintain biological functions. O acts as the final acceptor of electrons during oxidative...
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| Published in: | Biomedicines 2020-02, Vol.8 (2), p.32 |
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| container_title | Biomedicines |
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| creator | Hirota, Kiichi |
| description | Oxygen (O
) is essential for human life. Molecular oxygen is vital for the production of adenosine triphosphate (ATP) in human cells. O
deficiency leads to a reduction in the energy levels that are required to maintain biological functions. O
acts as the final acceptor of electrons during oxidative phosphorylation, a series of ATP synthesis reactions that occur in conjunction with the electron transport system in mitochondria. Persistent O
deficiency may cause death due to malfunctioning biological processes. The above account summarizes the classic view of oxygen. However, this classic view has been reviewed over the last two decades. Although O
is essential for life, higher organisms such as mammals are unable to biosynthesize molecular O
in the body. Because the multiple organs of higher organisms are constantly exposed to the risk of "O
deficiency," living organisms have evolved elaborate strategies to respond to hypoxia. In this review, I will describe the system that governs oxygen homeostasis in the living body from the point-of-view of the transcription factor hypoxia-inducible factor (HIF). |
| doi_str_mv | 10.3390/biomedicines8020032 |
| format | article |
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) is essential for human life. Molecular oxygen is vital for the production of adenosine triphosphate (ATP) in human cells. O
deficiency leads to a reduction in the energy levels that are required to maintain biological functions. O
acts as the final acceptor of electrons during oxidative phosphorylation, a series of ATP synthesis reactions that occur in conjunction with the electron transport system in mitochondria. Persistent O
deficiency may cause death due to malfunctioning biological processes. The above account summarizes the classic view of oxygen. However, this classic view has been reviewed over the last two decades. Although O
is essential for life, higher organisms such as mammals are unable to biosynthesize molecular O
in the body. Because the multiple organs of higher organisms are constantly exposed to the risk of "O
deficiency," living organisms have evolved elaborate strategies to respond to hypoxia. In this review, I will describe the system that governs oxygen homeostasis in the living body from the point-of-view of the transcription factor hypoxia-inducible factor (HIF).</description><identifier>ISSN: 2227-9059</identifier><identifier>EISSN: 2227-9059</identifier><identifier>DOI: 10.3390/biomedicines8020032</identifier><identifier>PMID: 32069878</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>hif-1 ; hypoxia ; hypoxia sensing ; hypoxia-inducible factor 1 ; Review ; transcription factor</subject><ispartof>Biomedicines, 2020-02, Vol.8 (2), p.32</ispartof><rights>2020 by the author. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-f96f44d8b76bc1eee694365718b26b85091754a02eef4749a6ae3de32f7111423</citedby><cites>FETCH-LOGICAL-c537t-f96f44d8b76bc1eee694365718b26b85091754a02eef4749a6ae3de32f7111423</cites><orcidid>0000-0003-1110-0827</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168341/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168341/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32069878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirota, Kiichi</creatorcontrib><title>Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and its Implication for Medicine</title><title>Biomedicines</title><addtitle>Biomedicines</addtitle><description>Oxygen (O
) is essential for human life. Molecular oxygen is vital for the production of adenosine triphosphate (ATP) in human cells. O
deficiency leads to a reduction in the energy levels that are required to maintain biological functions. O
acts as the final acceptor of electrons during oxidative phosphorylation, a series of ATP synthesis reactions that occur in conjunction with the electron transport system in mitochondria. Persistent O
deficiency may cause death due to malfunctioning biological processes. The above account summarizes the classic view of oxygen. However, this classic view has been reviewed over the last two decades. Although O
is essential for life, higher organisms such as mammals are unable to biosynthesize molecular O
in the body. Because the multiple organs of higher organisms are constantly exposed to the risk of "O
deficiency," living organisms have evolved elaborate strategies to respond to hypoxia. In this review, I will describe the system that governs oxygen homeostasis in the living body from the point-of-view of the transcription factor hypoxia-inducible factor (HIF).</description><subject>hif-1</subject><subject>hypoxia</subject><subject>hypoxia sensing</subject><subject>hypoxia-inducible factor 1</subject><subject>Review</subject><subject>transcription factor</subject><issn>2227-9059</issn><issn>2227-9059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptUU1r3DAQFaWlCdv8gkLRsZdt9WXJuhSa0O0uJBRKehZjebxRsC1X8obuv6-S3YQEMhcN82bejN4j5CNnX6S07GsT4oBt8GHEXDPBmBRvyKkQwiwtq-zbZ_kJOcv5lpWwXNZcvScnUjBta1OfkuEccvD0PMQ-bvc0dnS9n-K_UvqNeYpjxkyvyiKYsaXNns43SK8TjNmnMM0hjnQFfo6JrjerTGFsaZgz3QxTHzw84F0Br46nfiDvOugznh3fBfmz-nF9sV5e_vq5ufh-ufSVNPOys7pTqq0boxvPEVFbJXVleN0I3dRV-YipFDCB2CmjLGhA2aIUneGcKyEXZHPgbSPcuimFAdLeRQjuoRDT1kGag-_RtUabVhrdMgVKKmi0V2C7Il6jtS6KLci3A9e0a4rkHsc5Qf-C9CUyhhu3jXfOcF1LdU_w-UiQ4t8d5tkNIXvsexgx7rITsqorq4SoSqs8tPoUc07YPa3hzN377l7xvUx9en7h08yjy_I_udCs7w</recordid><startdate>20200213</startdate><enddate>20200213</enddate><creator>Hirota, Kiichi</creator><general>MDPI</general><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1110-0827</orcidid></search><sort><creationdate>20200213</creationdate><title>Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and its Implication for Medicine</title><author>Hirota, Kiichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-f96f44d8b76bc1eee694365718b26b85091754a02eef4749a6ae3de32f7111423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>hif-1</topic><topic>hypoxia</topic><topic>hypoxia sensing</topic><topic>hypoxia-inducible factor 1</topic><topic>Review</topic><topic>transcription factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirota, Kiichi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Biomedicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirota, Kiichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and its Implication for Medicine</atitle><jtitle>Biomedicines</jtitle><addtitle>Biomedicines</addtitle><date>2020-02-13</date><risdate>2020</risdate><volume>8</volume><issue>2</issue><spage>32</spage><pages>32-</pages><issn>2227-9059</issn><eissn>2227-9059</eissn><abstract>Oxygen (O
) is essential for human life. Molecular oxygen is vital for the production of adenosine triphosphate (ATP) in human cells. O
deficiency leads to a reduction in the energy levels that are required to maintain biological functions. O
acts as the final acceptor of electrons during oxidative phosphorylation, a series of ATP synthesis reactions that occur in conjunction with the electron transport system in mitochondria. Persistent O
deficiency may cause death due to malfunctioning biological processes. The above account summarizes the classic view of oxygen. However, this classic view has been reviewed over the last two decades. Although O
is essential for life, higher organisms such as mammals are unable to biosynthesize molecular O
in the body. Because the multiple organs of higher organisms are constantly exposed to the risk of "O
deficiency," living organisms have evolved elaborate strategies to respond to hypoxia. In this review, I will describe the system that governs oxygen homeostasis in the living body from the point-of-view of the transcription factor hypoxia-inducible factor (HIF).</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>32069878</pmid><doi>10.3390/biomedicines8020032</doi><orcidid>https://orcid.org/0000-0003-1110-0827</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Biomedicines, 2020-02, Vol.8 (2), p.32 |
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| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_d767d376d04a434ab6c4a9f227b66691 |
| source | PubMed (Medline); Publicly Available Content (ProQuest) |
| subjects | hif-1 hypoxia hypoxia sensing hypoxia-inducible factor 1 Review transcription factor |
| title | Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and its Implication for Medicine |
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