Dietary Rice Bran-Modified Human Gut Microbial Consortia Confers Protection against Colon Carcinogenesis Following Fecal Transfaunation

Rice bran, removed from whole grain rice for white rice milling, has demonstrated efficacy for the control and suppression of colitis and colon cancer in multiple animal models. Dietary rice bran intake was shown to modify human stool metabolites as a result of modifications to metabolism by gut mic...

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Published in:Biomedicines 2021-02, Vol.9 (2), p.144
Main Authors: Parker, Kristopher D, Maurya, Akhilendra K, Ibrahim, Hend, Rao, Sangeeta, Hove, Petronella R, Kumar, Dileep, Kant, Rama, Raina, Bupinder, Agarwal, Rajesh, Kuhn, Kristine A, Raina, Komal, Ryan, Elizabeth P
Format: Article
Language:English
Subjects:
Animal models
Azoxymethane
Carcinogenesis
Colitis
Colon cancer
colon cancer carcinogenesis
Colorectal cancer
Colorectal carcinoma
Dextran
Dietary intake
Drinking water
fecal microbiota transplantation
Fecal microflora
Feces
Germfree
Glycerol
Intestinal microflora
Metabolism
Metabolites
metabolome
microbiome
Microbiota
Rice
Sodium sulfate
Transplantation
Trimethylamine
Trimethylamine-N-oxide
Tumorigenesis
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Summary:Rice bran, removed from whole grain rice for white rice milling, has demonstrated efficacy for the control and suppression of colitis and colon cancer in multiple animal models. Dietary rice bran intake was shown to modify human stool metabolites as a result of modifications to metabolism by gut microbiota. In this study, human stool microbiota from colorectal cancer (CRC) survivors that consumed rice bran daily was examined by fecal microbiota transplantation (FMT) for protection from azoxymethane and dextran sodium sulfate (AOM/DSS) induced colon carcinogenesis in germ-free mice. Mice transfaunated with rice bran-modified microbiota communities (RMC) harbored fewer neoplastic lesions in the colon and displayed distinct enrichment of and associated with colon health, and the depletion of correlated with increased tumor burden. Two anti-cancer metabolites, myristoylcarnitine and palmitoylcarnitine were increased in the colon of RMC transplanted mice. Trimethylamine-N-oxide (TMAO) and tartarate that are implicated in CRC development were reduced in murine colon tissue after FMT with rice bran-modified human microbiota. Findings from this study show that rice bran modified gut microbiota from humans confers protection from colon carcinogenesis in mice and suggests integrated dietary-FMT intervention strategies should be tested for colorectal cancer control, treatment, and prevention.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines9020144