Mast Cell Regulation and Irritable Bowel Syndrome: Effects of Food Components with Potential Nutraceutical Use

Mast cells are key actors in inflammatory reactions. Upon activation, they release histamine, heparin and nerve growth factor, among many other mediators that modulate immune response and neuron sensitization. One important feature of mast cells is that their population is usually increased in anima...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-09, Vol.25 (18), p.4314
Main Authors: Uranga, José Antonio, Martínez, Vicente, Abalo, Raquel
Format: Article
Language:English
Subjects:
Abdominal Pain - metabolism
Amino Acids - chemistry
Amino Acids - metabolism
Animals
cannabidiol
Cannabidiol - metabolism
Constipation - metabolism
Diarrhea - metabolism
Dietary Supplements
Eating - physiology
fatty acids
Fatty Acids - chemistry
Fatty Acids - metabolism
Flavonoids - chemistry
Flavonoids - metabolism
heparin
Heparin - metabolism
histamine
Histamine - metabolism
Humans
Intestinal Mucosa - metabolism
irritable bowel syndrome
Irritable Bowel Syndrome - metabolism
mast cells
Mast Cells - metabolism
Nerve Growth Factor - metabolism
Polyphenols - metabolism
Quality of Life
Review
Vitamins - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mast cells are key actors in inflammatory reactions. Upon activation, they release histamine, heparin and nerve growth factor, among many other mediators that modulate immune response and neuron sensitization. One important feature of mast cells is that their population is usually increased in animal models and biopsies from patients with irritable bowel syndrome (IBS). Therefore, mast cells and mast cell mediators are regarded as key components in IBS pathophysiology. IBS is a common functional gastrointestinal disorder affecting the quality of life of up to 20% of the population worldwide. It is characterized by abdominal pain and altered bowel habits, with heterogeneous phenotypes ranging from constipation to diarrhea, with a mixed subtype and even an unclassified form. Nutrient intake is one of the triggering factors of IBS. In this respect, certain components of the daily food, such as fatty acids, amino acids or plant-derived substances like flavonoids, have been described to modulate mast cells' activity. In this review, we will focus on the effect of these molecules, either stimulatory or inhibitory, on mast cell degranulation, looking for a nutraceutical capable of decreasing IBS symptoms.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25184314