Association between visit-to-visit fasting glycemic variability and depression: a retrospective cohort study in a representative Korean population without diabetes

Glycemic variability (GV) is a risk factor for depression in patients with diabetes. However, whether it is also a predictor of incident depression in people without diabetes remains unclear. We aimed to investigate the association between visit-to-visit variability in fasting serum glucose (FSG) le...

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Published in:Scientific reports 2022-11, Vol.12 (1), p.18692-18692, Article 18692
Main Authors: Kim, Hye Jun, Kim, Sung Min, Lee, Gyeongsil, Choi, Seulggie, Son, Joung Sik, Oh, Yun Hwan, Choi, Soo Jung, Jeong, Seogsong, Park, Sang Min
Format: Article
Language:English
Subjects:
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Blood Glucose
Cohort analysis
Cohort Studies
Depression - epidemiology
Diabetes
Diabetes mellitus
Diabetes Mellitus - epidemiology
Diabetes Mellitus, Type 2 - complications
Fasting
Humanities and Social Sciences
Humans
Medical screening
Mental depression
multidisciplinary
Republic of Korea - epidemiology
Retrospective Studies
Risk Factors
Risk reduction
Science
Science (multidisciplinary)
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Summary:Glycemic variability (GV) is a risk factor for depression in patients with diabetes. However, whether it is also a predictor of incident depression in people without diabetes remains unclear. We aimed to investigate the association between visit-to-visit variability in fasting serum glucose (FSG) levels and the incidence of depression among Koreans without diabetes. This retrospective cohort study included data of people without diabetes who did not have depression at baseline and had at least three FSG measurements (n = 264,480) extracted from the 2002–2007 Korean National Health Insurance Service–National Health Screening Cohort. GV was calculated as the average successive variability of FSG. Among 264,480 participants, 198,267 were observed during 2008–2013 and their hazard ratios (HR) of incident depression were calculated. Participants with the highest GV showed a higher risk of depression in fully adjusted models than those with the lowest GV (HR, 1.09; 95% CI, 1.02–1.16). The risk of incident depression heightened with increasing GV ( p for trend 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-22302-0