An Update of Research Animal Models of Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a group of chronic disorders that includes two main disease forms, Crohn’s disease, and ulcerative colitis. The understanding of the intestinal inflammation occurring in IBD has been immeasurably advanced by the development of the now numerous murine models of int...

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Bibliographic Details
Published in:TheScientificWorld 2021, Vol.2021, p.7479540-12
Main Authors: Baydi, Zineb, Limami, Youness, Khalki, Loubna, Zaid, Nabil, Naya, Abdallah, Mtairag, El Mostafa, Oudghiri, Mounia, Zaid, Younes
Format: Article
Language:English
Subjects:
Alcohol
Analysis
Animal diseases
Animal models
Animals
Crohn's disease
Disease Models, Animal
Disease susceptibility
Environmental factors
Ethanol
Genes
Health aspects
Immune system
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - genetics
Inflammatory Bowel Diseases - immunology
Inflammatory Bowel Diseases - microbiology
Intestinal microflora
Intestine
Irritable bowel syndrome
Medical research
Medicine, Experimental
Mice
Microbiota
Pathology
Review
Rodents
Ulcerative colitis
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Summary:Inflammatory bowel disease (IBD) is a group of chronic disorders that includes two main disease forms, Crohn’s disease, and ulcerative colitis. The understanding of the intestinal inflammation occurring in IBD has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation. The usefulness of this research tool in IBD arises from a convergence of underlying genetic susceptibility, immune system dysfunction, environmental factors, and shifts in gut microbiota. Due to the multifactorial feature of these diseases, different animal models have been used to investigate the underlying mechanisms and develop potential therapeutic strategies. The results of preclinical efficacy studies often inform the progression of therapeutic strategies. This review describes the distinct feature and limitations of each murine IBD model and discusses the previous and current lessons from the IBD models.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2021/7479540