BA11 FKBP5 expression levels correlate with dendritic spine density in postmortem PTSD and controls

Genetic variants of the immunophilin FKBP5 have been implicated in susceptibility to post-traumatic stress disorder (PTSD) and other stress-related disorders. We examined the relationship between mushroom, stubby, thin and filopodial spine densities measured with Golgi staining and FKBP5 gene expres...

Full description

Saved in:
Bibliographic Details
Published in:Neurobiology of stress 2015-01, Vol.2 (C), p.67-72
Main Authors: Young, Keith A., Thompson, Peter M., Cruz, Dianne A., Williamson, Douglas E., Selemon, Lynn D.
Format: Article
Language:English
Subjects:
Dendritic spine
FKBP5
Original
Post-mortem
Post-traumatic stress disorder
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Genetic variants of the immunophilin FKBP5 have been implicated in susceptibility to post-traumatic stress disorder (PTSD) and other stress-related disorders. We examined the relationship between mushroom, stubby, thin and filopodial spine densities measured with Golgi staining and FKBP5 gene expression in the medial orbitofrontal cortex (BA11) in individuals diagnosed with PTSD and normal controls (n = 8/8). ANCOVA revealed PTSD cases had a significantly elevated density of stubby spines (29%, P 
ISSN:2352-2895
2352-2895
DOI:10.1016/j.ynstr.2015.07.002