Pneumonitis associated with pembrolizumab plus chemotherapy for non-squamous non-small cell lung cancer

Studies elucidating detailed characteristics of pneumonitis in association with chemo-immunotherapy are limited. We aimed to investigate the characteristics of images, prognostic factors, and clinical course of combination therapy associated with pneumonitis. A multicenter, retrospective cohort stud...

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Bibliographic Details
Published in:Scientific reports 2023-03, Vol.13 (1), p.3698-3698, Article 3698
Main Authors: Fujimoto, Daichi, Miura, Satoru, Tomii, Keisuke, Sumikawa, Hiromitsu, Yoshimura, Kenichi, Wakuda, Kazushige, Oya, Yuko, Yokoyama, Toshihide, Kijima, Takashi, Asao, Tetsuhiko, Tamiya, Motohiro, Nakamura, Atsushi, Yoshioka, Hiroshige, Tokito, Takaaki, Murakami, Shuji, Tamiya, Akihiro, Yokouchi, Hiroshi, Watanabe, Satoshi, Yamaguchi, Ou, Morinaga, Ryotaro, Jodai, Takayuki, Ito, Kentaro, Shiraishi, Yoshimasa, Kogure, Yoshihito, Shibaki, Ryota, Yamamoto, Nobuyuki
Format: Article
Language:English
Subjects:
631/67/1612/1350
692/499
692/699/1785
Alveoli
Carcinoma, Non-Small-Cell Lung - drug therapy
Chemotherapy
Clinical trials
Diagnosis
Disease Progression
Humanities and Social Sciences
Humans
Immunotherapy
Lung cancer
Lung Neoplasms - drug therapy
Medical prognosis
multidisciplinary
Non-small cell lung carcinoma
Patients
Pembrolizumab
Pneumonia
Pneumonitis
Respiration
Retrospective Studies
Science
Science (multidisciplinary)
Small cell lung carcinoma
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Summary:Studies elucidating detailed characteristics of pneumonitis in association with chemo-immunotherapy are limited. We aimed to investigate the characteristics of images, prognostic factors, and clinical course of combination therapy associated with pneumonitis. A multicenter, retrospective cohort study of patients with non-squamous non-small cell lung cancer who received a combination of platinum, pemetrexed, and pembrolizumab was conducted. Patients with confirmed pneumonitis established by an independent multidisciplinary team were enrolled. For 53 patients with pneumonitis, radiographic features at diagnosis predominantly comprised an organizing pneumonia pattern (62%, 33/53). Twelve (23%) patients experienced a worsening respiratory status during pneumonitis management, which was associated with a high mortality rate (58%, 7/12) during treatment. Severe grade at pneumonitis diagnosis ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-30676-y