Molecular detection of leptospirosis and melioidosis co-infection: A case report

Abstract Leptospirosis and melioidosis are important tropical infections caused by Leptospira and Burkholdheria pseudomallei , respectively. As both infections share similar clinical manifestations yet require different managements, complementary laboratory tests are crucial for the diagnosis. We de...

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Bibliographic Details
Published in:Journal of infection and public health 2017-11, Vol.10 (6), p.894-896
Main Authors: Mohd Ali, Mohammad Ridhuan, Mohamad Safiee, Amira Wahida, Thangarajah, Padmaloseni, Fauzi, Mohd Hashairi, Muhd Besari, Alwi, Ismail, Nabilah, Yean Yean, Chan
Format: Article
Language:English
Subjects:
Adult
Burkholderia pseudomallei - isolation & purification
Co-infection
Coinfection - diagnosis
Coinfection - pathology
Diabetes Complications
Febrile
Female
Humans
Infectious Disease
Internal Medicine
Leptospira - isolation & purification
Leptospirosis
Leptospirosis - diagnosis
Leptospirosis - pathology
Malaysia
Melioidosis
Melioidosis - diagnosis
Melioidosis - pathology
PCR
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Summary:Abstract Leptospirosis and melioidosis are important tropical infections caused by Leptospira and Burkholdheria pseudomallei , respectively. As both infections share similar clinical manifestations yet require different managements, complementary laboratory tests are crucial for the diagnosis. We describe a case of Leptospira and B. pseudomallei co-infection in a diabetic 40-year-old woman with history of visit to a freshwater camping site in northern Malaysia. To our knowledge, this is the first case of such double-infection, simultaneously demonstrated by molecular approach. This case highlights the possibility of leptospirosis and melioidosis co-infections and their underlying challenges in the rapid and accurate detection of the etiologic microorganism.
ISSN:1876-0341
1876-035X
DOI:10.1016/j.jiph.2017.02.009