Studies in upper extremity deep vein thrombosis: Addressing the knowledge gaps

In this issue of RPTH, Woller and colleagues report the protocol for a large prospective management cohort (the ARM‐DVT study) aiming to assess the use of apixaban at standard doses for 12 weeks in patients diagnosed with UEDVT involving any vein from the ulnar and radial to the internal jugular. Tw...

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Bibliographic Details
Published in:Research and practice in thrombosis and haemostasis 2019-07, Vol.3 (3), p.312-314
Main Author: Lazo‐Langner, Alejandro
Format: Article
Language:English
Subjects:
Anticoagulants
Cancer
Catheters
Commentaries
Embolisms
Population
Studies
Thromboembolism
Thrombosis
Tumors
Veins & arteries
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Summary:In this issue of RPTH, Woller and colleagues report the protocol for a large prospective management cohort (the ARM‐DVT study) aiming to assess the use of apixaban at standard doses for 12 weeks in patients diagnosed with UEDVT involving any vein from the ulnar and radial to the internal jugular. Two previous prospective studies evaluating the use of low‐molecular‐weight heparin (LMWH) followed by warfarin in patients with both forms of UEDVT found that anticoagulation alone seems to be equally effective in preventing thrombotic recurrences in either type. [...]for any study in this area it is important to evaluate thrombosis recurrence according to the subtype of UEDVT. To date, no study has compared anticoagulation versus active surveillance in either UEDVT or DVT of the lower extremity, but a recent randomized trial in patients with isolated DVT of the calf comparing nadroparin with placebo found that anticoagulation did not reduce the risk of proximal extension and increased the risk of bleeding. [...]the optimal duration of anticoagulant treatment in this population is not well established.
ISSN:2475-0379
2475-0379
DOI:10.1002/rth2.12210