Advances of Hydrogel-Based Bioprinting for Cartilage Tissue Engineering

Bioprinting has gained immense attention and achieved the revolutionized progress for application in the multifunctional tissue regeneration. On account of the precise structural fabrication and mimicking complexity, hydrogel-based bio-inks are widely adopted for cartilage tissue engineering. Althou...

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Bibliographic Details
Published in:Frontiers in bioengineering and biotechnology 2021-09, Vol.9, p.746564-746564
Main Authors: Han, Xue, Chang, Shuai, Zhang, Mingming, Bian, Xiangbing, Li, Chunlin, Li, Dawei
Format: Article
Language:English
Subjects:
bio-ink
Bioengineering and Biotechnology
bioprinting hydrogel
cartilage repair
polysaccharides
tissue engineering
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Summary:Bioprinting has gained immense attention and achieved the revolutionized progress for application in the multifunctional tissue regeneration. On account of the precise structural fabrication and mimicking complexity, hydrogel-based bio-inks are widely adopted for cartilage tissue engineering. Although more and more researchers have reported a number of literatures in this field, many challenges that should be addressed for the development of three-dimensional (3D) bioprinting constructs still exist. Herein, this review is mainly focused on the introduction of various natural polymers and synthetic polymers in hydrogel-based bioprinted scaffolds, which are systematically discussed via emphasizing on the fabrication condition, mechanical property, biocompatibility, biodegradability, and biological performance for cartilage tissue repair. Further, this review describes the opportunities and challenges of this 3D bioprinting technique to construct complex bio-inks with adjustable mechanical and biological integrity, and meanwhile, the current possible solutions are also conducted for providing some suggestive ideas on developing more advanced bioprinting products from the bench to the clinic.
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2021.746564