Free zinc determines the formability of the vesicular dense core in diabetic beta cells

During the progression of type 2 diabetes, total body zinc deficiency disrupts the formability of the electron-dense core in beta-cell vesicles, but the mechanism is unclear. Using fluorescence imaging, transmission electron microscopy and pharmacokinetics assays, we established a strong link betwee...

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Bibliographic Details
Published in:Cell insight 2022-04, Vol.1 (2), p.100020-100020, Article 100020
Main Authors: Xian, Yi, Zhou, Mengxuan, Hu, Yuanzhao, Liu, Jing, Zhu, Wenzhen, Wang, Yi
Format: Article
Language:English
Subjects:
Beta cell
Dense core
Diabetes
Glucose
Insulin
Letter to the Editor
Zinc
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Summary:During the progression of type 2 diabetes, total body zinc deficiency disrupts the formability of the electron-dense core in beta-cell vesicles, but the mechanism is unclear. Using fluorescence imaging, transmission electron microscopy and pharmacokinetics assays, we established a strong link between an increasing concentration of free zinc and the formability enhancement of the dense core electron density. Thus, our results highlight a mechanism by which zinc supplementation enhances the maturation of dense cores and restores the secretion of insulin in two diabetic mouse models both in vitro and in vivo. This study provides a potential research direction for investigating the etiology and nutrition of zinc in the management of type 2 diabetes.
ISSN:2772-8927
2772-8927
DOI:10.1016/j.cellin.2022.100020