Interdisciplinary Approaches to Deal with Alzheimer's Disease-From Bench to Bedside: What Feasible Options Do Already Exist Today?

• Published in: Biomedicines 2022-11, Vol.10 (11), p.2922
• Main Authors: Ablinger, Irene, Dressel, Katharina, Rott, Thea, Lauer, Anna Andrea, Tiemann, Michael, Batista, João Pedro, Taddey, Tim, Grimm, Heike Sabine, Grimm, Marcus Otto Walter
• Format: Article
• Language: English
• Subjects: Alzheimer's disease; Amyloidogenesis; Caregivers; Cognition; Cognition & reasoning; cognition-oriented treatment; Cognitive ability; Communication; Dementia; Dental plaque; Diabetes; Enzymes; Life span; Lipids; Memory; Molecular modelling; Neurodegenerative diseases; nutritional approaches; Oxidative stress; Pathogenesis; Pathology; Peptides; Periodontitis; Phosphatase; Physical activity; Physiological aspects; Physiology; Proteins; Quality of life; Review; Social interaction; socioeconomic factors; Tau protein
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines10112922

Alzheimer's disease is one of the most common neurodegenerative diseases in the western population. The incidence of this disease increases with age. Rising life expectancy and the resulting increase in the ratio of elderly in the population are likely to exacerbate socioeconomic problems. Alzheimer's disease is a multifactorial disease. In addition to amyloidogenic processing leading to plaques, and tau pathology, but also other molecular causes such as oxidative stress or inflammation play a crucial role. We summarize the molecular mechanisms leading to Alzheimer's disease and which potential interventions are known to interfere with these mechanisms, focusing on nutritional approaches and physical activity but also the beneficial effects of cognition-oriented treatments with a focus on language and communication. Interestingly, recent findings also suggest a causal link between oral conditions, such as periodontitis or edentulism, and Alzheimer's disease, raising the question of whether dental intervention in Alzheimer's patients can be beneficial as well. Unfortunately, all previous single-domain interventions have been shown to have limited benefit to patients. However, the latest studies indicate that combining these efforts into multidomain approaches may have increased preventive or therapeutic potential. Therefore, as another emphasis in this review, we provide an overview of current literature dealing with studies combining the above-mentioned approaches and discuss potential advantages compared to monotherapies. Considering current literature and intervention options, we also propose a multidomain interdisciplinary approach for the treatment of Alzheimer's disease patients that synergistically links the individual approaches. In conclusion, this review highlights the need to combine different approaches in an interdisciplinary manner, to address the future challenges of Alzheimer's disease.