Interleukin 10 gene polymorphisms and frailty syndrome in elderly Mexican people: (Sadem study)

• Published in: Molecular genetics & genomic medicine 2019-09, Vol.7 (9), p.e918-n/a
• Main Authors: Juárez‐Cedillo, Teresa, Vargas‐Alarcón, Gilberto, Martínez‐Rodríguez, Nancy, Juárez‐Cedillo, Enrique, Fragoso, José Manuel, Escobedo‐de‐la‐Peña, Jorge
• Format: Article
• Language: English
• Subjects: Activities of daily living; Age; Aged; Aging; Cognitive ability; Comorbidity; Cytokines; Dementia; Deoxyribonucleic acid; DNA; Female; Frailty; Frailty - epidemiology; Frailty - genetics; Genetic Predisposition to Disease; geriatric syndrome; Geriatrics; Haplotypes; Humans; Inflammation; interleukin; Interleukin 1; Interleukin 10; Interleukin-10 - genetics; Interleukins; Male; Mexico - epidemiology; Middle Aged; Models, Genetic; Morbidity; Older people; Original; Polymorphism, Single Nucleotide; polymorphisms; Population; Population studies; Studies
• ISSN: 2324-9269; 2324-9269
• DOI: 10.1002/mgg3.918

Frailty is a geriatric syndrome, characterized by a loss in functional reserve with an increase in morbidity and mortality. There are no reports that link the genetic polymorphisms between interleukin 10 (IL10) and frailty; for this reason, our objective was used to analyze the role of the polymorphisms of IL10 (rs1800896, rs1800871) in the susceptibility to frailty in a Mexican population. Our study included 984 participants divided into 368 nonfrail, 309 prefrail, and 307 frail. The models for the polymorphisms rs1800896 and rs1800871 were recessive models in association with frailty (OR = 2.3, CI 95% = 1.6–3.2; OR = 1.53, CI 95% = 1.0–2.6), respectively. Two risk haplotypes were identified: ACG and CCG (p