Evaluation of Ki-67 expression in feline non-ocular melanocytic tumours

Melanomas are rare in cats. The eye is the most commonly involved site, whereas few data are available about feline non-ocular melanomas (NOMs). Ki-67 thresholds with prognostic relevance have been established for canine melanomas, but not in cats. This study was undertaken to investigate the relati...

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Bibliographic Details
Published in:BMC veterinary research 2018-10, Vol.14 (1), p.309-309, Article 309
Main Authors: Sabattini, Silvia, Renzi, Andrea, Albanese, Francesco, Fantinati, Marco, Rigillo, Antonella, Abramo, Francesca, Tornago, Raimondo, Tortorella, Giovanni, Massaro, Maria, Pagano, Teresa Bruna, Buchholz, Julia, Bettini, Giuliano
Format: Article
Language:English
Subjects:
Balloon treatment
Bleaching
Care and treatment
Cell morphology
Cell proliferation
Clinical outcomes
Cytology
Evaluation
Feline
Gene expression
Histology
Information retrieval
Ki-67 index
Medical prognosis
Melanoma
Mitotic count
Morphology
Mucosa
Pigmentation
Population studies
Prognosis
Proliferative activity
Skin
Studies
Tumors
Veterinary surgeons
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Summary:Melanomas are rare in cats. The eye is the most commonly involved site, whereas few data are available about feline non-ocular melanomas (NOMs). Ki-67 thresholds with prognostic relevance have been established for canine melanomas, but not in cats. This study was undertaken to investigate the relationship between Ki-67 index, tumour characteristics, and clinical outcome in feline NOMs. Histologic samples were retrospectively reviewed. Amelanotic tumours were admitted upon immunohistochemical positivity for Melan A or S100. Evaluated parameters included morphological diagnosis, histotype, junctional activity, degree of pigmentation, vascular invasion, lymphocytic infiltrate, necrosis, mitotic count (MC) and Ki-67 index. Pigmented tumours were bleached before evaluation. Clinical and follow-up information were retrieved via telephone interviews with the referring veterinarians. Fifty tumours located in skin (n = 33) and mucosae (n = 17) were included. Forty-eight percent and 95% of amelanotic tumours (n = 21) stained positive for Melan A and S100, respectively. Most achromic tumours were mucosal (P 
ISSN:1746-6148
1746-6148
DOI:10.1186/s12917-018-1639-1