Distinct abdominal and gluteal adipose tissue transcriptome signatures are altered by exercise training in African women with obesity

The differential associations of adipose depots with metabolic risk during obesity have been proposed to be controlled by environmental and genetic factors. We evaluated the regional differences in transcriptome signatures between abdominal (aSAT) and gluteal subcutaneous adipose tissue (gSAT) in ob...

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Bibliographic Details
Published in:Scientific reports 2020-06, Vol.10 (1), p.10240-10240, Article 10240
Main Authors: Nono Nankam, Pamela A., Blüher, Matthias, Kehr, Stephanie, Klöting, Nora, Krohn, Knut, Adams, Kevin, Stadler, Peter F., Mendham, Amy E., Goedecke, Julia H.
Format: Article
Language:English
Subjects:
631/208/199
631/443/319/1642/393
Adipose tissue
Adult
African Continental Ancestry Group - genetics
Body composition
Body fat
Body weight
Buttocks
DNA-Binding Proteins - genetics
Embryogenesis
Embryonic growth stage
Exercise
Exercise Therapy
Female
Fitness training programs
Gene expression
Gene Expression Profiling - methods
Gene Expression Regulation
Gene Regulatory Networks
Genetic factors
Homeodomain Proteins - genetics
Humanities and Social Sciences
Humans
Inflammation
Intra-Abdominal Fat - chemistry
Lipid metabolism
multidisciplinary
Obesity
Obesity - genetics
Obesity - metabolism
Obesity - rehabilitation
Organ Specificity
Oxygen - metabolism
Oxygen consumption
Physical training
Resistance Training
Science
Science (multidisciplinary)
Subcutaneous Fat - chemistry
Transcription Factors - genetics
Young Adult
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Summary:The differential associations of adipose depots with metabolic risk during obesity have been proposed to be controlled by environmental and genetic factors. We evaluated the regional differences in transcriptome signatures between abdominal (aSAT) and gluteal subcutaneous adipose tissue (gSAT) in obese black South African women and tested the hypothesis that 12-week exercise training alters gene expression patterns in a depot-specific manner. Twelve young women performed 12-weeks of supervised aerobic and resistance training. Pre- and post-intervention measurements included peak oxygen consumption (VO 2peak ), whole-body composition and unbiased gene expression analysis of SAT depots. VO 2peak increased, body weight decreased, and body fat distribution improved with exercise training (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-66868-z