Risk Factors for Development and Severity of COVID-19 in COPD Patients

The impact that COVID-19 could have on patients with COPD is a real concern. In this study we evaluated, in a cohort of longitudinally followed COPD subjects, the incidence of COVID-19, seeking for possible risk factors and prognostic factors predicting the clinical outcome. In our cohort of 370 pat...

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Published in:Frontiers in medicine 2021-08, Vol.8, p.714570-714570
Main Authors: Bonato, Matteo, Semenzato, Umberto, Tinè, Mariaenrica, Bazzan, Erica, Damin, Marco, Biondini, Davide, Casara, Alvise, Romagnoli, Micaela, Turato, Graziella, Cosio, Manuel G., Saetta, Marina, Baraldo, Simonetta
Format: Article
Language:English
Subjects:
clinical outcome
COPD comorbidities
COVID-19
DLCO
emphysema
Medicine
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Summary:The impact that COVID-19 could have on patients with COPD is a real concern. In this study we evaluated, in a cohort of longitudinally followed COPD subjects, the incidence of COVID-19, seeking for possible risk factors and prognostic factors predicting the clinical outcome. In our cohort of 370 patients (followed for 5.3 ± 2.7 years), 22 developed COVID-19 (COPD/COVID-19+) between February/November 2020 (5.9%). Cardio-metabolic conditions (hypertension, dyslipidemia, obesity, diabetes) but not respiratory abnormalities (FEV 1 , DLCO, emphysema and exacerbation history), were risk factors for development of COVID-19 in COPD patients. Out of the 22 COPD/COVID-19+ patients, 10 needed intensive care. Low DLCO and emphysema, but also metabolic comorbidities, were related to the need for intensive care.
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2021.714570