Sensors and Biosensors for C-Reactive Protein, Temperature and pH, and Their Applications for Monitoring Wound Healing: A Review

Wound assessment is usually performed in hospitals or specialized labs. However, since patients spend most of their time at home, a remote real time wound monitoring would help providing a better care and improving the healing rate. This review describes the advances in sensors and biosensors for mo...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2017-12, Vol.17 (12), p.2952
Main Authors: Salvo, Pietro, Dini, Valentina, Kirchhain, Arno, Janowska, Agata, Oranges, Teresa, Chiricozzi, Andrea, Lomonaco, Tommaso, Di Francesco, Fabio, Romanelli, Marco
Format: Article
Language:English
Subjects:
Biosensors
C-reactive protein
Chemical sensors
Chemiluminescence
Electrical measurement
Field effect transistors
Fluorescence
Immunosensors
Potentiometric analysis
Remote monitoring
Review
Semiconductor devices
Sensors
temperature
Wound healing
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Summary:Wound assessment is usually performed in hospitals or specialized labs. However, since patients spend most of their time at home, a remote real time wound monitoring would help providing a better care and improving the healing rate. This review describes the advances in sensors and biosensors for monitoring the concentration of C-reactive protein (CRP), temperature and pH in wounds. These three parameters can be used as qualitative biomarkers to assess the wound status and the effectiveness of therapy. CRP biosensors can be classified in: (a) field effect transistors, (b) optical immunosensors based on surface plasmon resonance, total internal reflection, fluorescence and chemiluminescence, (c) electrochemical sensors based on potentiometry, amperometry, and electrochemical impedance, and (d) piezoresistive sensors, such as quartz crystal microbalances and microcantilevers. The last section reports the most recent developments for wearable non-invasive temperature and pH sensors suitable for wound monitoring.
ISSN:1424-8220
1424-8220
DOI:10.3390/s17122952