Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life

Membrane proteins can be classified into two main categories-integral and peripheral membrane proteins-depending on the nature of their membrane interaction. Peripheral membrane proteins are highly unique amphipathic proteins that interact with the membrane indirectly, using electrostatic or hydroph...

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Bibliographic Details
Published in:Membranes (Basel) 2021-05, Vol.11 (5), p.346
Main Authors: Boes, Deborah M, Godoy-Hernandez, Albert, McMillan, Duncan G G
Format: Article
Language:English
Subjects:
Acetylcholinesterase
African trypanosomiasis
Alkaline phosphatase
Alternative oxidase
Arteriosclerosis
Atherosclerosis
Bacteria
Binding sites
Cell membranes
Cytochrome
Cytochrome c
Cytochromes
Dehydrogenase
Dihydroorotate dehydrogenase
drug targets
electrostatic interactions
Electrostatic properties
Enzymes
GPI-anchored proteins
Gram-negative bacteria
human diseases
hydrophobic membrane anchor
Hydrophobicity
Lipids
Membrane proteins
Membranes
NADH
NADH dehydrogenase
Nicotinamide adenine dinucleotide
Nitrate reductase
Nitrates
Nucleotidase
Pathogens
peripheral membrane proteins
Physiology
Proteins
Reductases
Review
Structure-function relationships
Tuberculosis
Vector-borne diseases
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Summary:Membrane proteins can be classified into two main categories-integral and peripheral membrane proteins-depending on the nature of their membrane interaction. Peripheral membrane proteins are highly unique amphipathic proteins that interact with the membrane indirectly, using electrostatic or hydrophobic interactions, or directly, using hydrophobic tails or GPI-anchors. The nature of this interaction not only influences the location of the protein in the cell, but also the function. In addition to their unique relationship with the cell membrane, peripheral membrane proteins often play a key role in the development of human diseases such as African sleeping sickness, cancer, and atherosclerosis. This review will discuss the membrane interaction and role of periplasmic nitrate reductase, CymA, cytochrome alkaline phosphatase, ecto-5'-nucleotidase, acetylcholinesterase, alternative oxidase, type-II NADH dehydrogenase, and dihydroorotate dehydrogenase in certain diseases. The study of these proteins will give new insights into their function and structure, and may ultimately lead to ground-breaking advances in the treatment of severe diseases.
ISSN:2077-0375
2077-0375
DOI:10.3390/membranes11050346