Association of novel dietary and lifestyle inflammation scores with incidence and progression of coronary artery calcification in middle-late adulthood: a longitudinal cohort study

Dietary patterns and lifestyle factors can influence the intensity of systemic inflammation and, consequently, the development and progression of coronary artery calcification (CAC). This study aimed to explore the relationship between the inflammatory potentials of diet and lifestyle, as captured b...

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Bibliographic Details
Published in:Nutrition journal 2024-10, Vol.23 (1), p.127-13, Article 127
Main Authors: Ramezankhani, Azra, Hadaegh, Parto, Hadaegh, Farzad
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
Calcification
Cardiovascular diseases
Care and treatment
Cohort Studies
Coronary artery calcium
Coronary Artery Disease - epidemiology
CT imaging
Diet
Diet - methods
Diet - statistics & numerical data
Disease Progression
Female
Health aspects
Humans
Incidence
Inflammation
Inflammation - epidemiology
Life Style
Lifestyle
Longitudinal Studies
Male
Middle Aged
Prevention
Proportional Hazards Models
Risk Factors
Score
Vascular Calcification - epidemiology
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Summary:Dietary patterns and lifestyle factors can influence the intensity of systemic inflammation and, consequently, the development and progression of coronary artery calcification (CAC). This study aimed to explore the relationship between the inflammatory potentials of diet and lifestyle, as captured by novel dietary and lifestyle inflammation scores (DIS and LIS), with CAC incidence and progression. We analyzed data on 5949 Black and White men and women ≥ 45 years old participating in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. Baseline data on diet and lifestyle factors were collected from 2000 to 2002 and used to construct the DIS and LIS, which reflect the overall inflammatory potential of diet and lifestyle. Cox proportional hazard regression was used to calculate the hazard ratios (HR) and 95% confidence intervals (95% CI) for CAC incidence and progression across quartiles of DIS and LIS, adjusting for potential confounders. Over a median follow-up of 8.0 years, among 2638 participants with zero CAC score at baseline, 977 individuals developed positive scores, and 1681 out of 2561 participants showed CAC progression. For individuals in the highest (more pro-inflammatory) compared to the lowest (more anti-inflammatory) quartiles of the LIS, the multivariable-adjusted HR for CAC incidence was 1.35 (95% CI, 1.10-1.65; P trend 
ISSN:1475-2891
1475-2891
DOI:10.1186/s12937-024-01028-x