Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompa...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-09, Vol.25 (18), p.4090
Main Authors: Chimisso, Vittoria, Aleman Garcia, Miguel Angel, Yorulmaz Avsar, Saziye, Dinu, Ionel Adrian, Palivan, Cornelia G
Format: Article
Language:English
Subjects:
Animals
bio-conjugated hydrogels
Biocompatibility
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biological activity
Biomedical materials
biomolecule
Biomolecules
Cell adhesion & migration
Cell growth
Chemical Phenomena
Design
Drug delivery systems
Growth factors
Humans
Hyaluronic acid
Hydrogels
Hydrogels - chemical synthesis
Hydrogels - chemistry
Mechanical Phenomena
Mechanical properties
Medicine
Peptides
Physical properties
polymer scaffold
Polymers
Polymers - chemistry
Proteins
Regenerative medicine
Regenerative Medicine - methods
Review
Scaffolds
Tissue Engineering
Tissue Scaffolds - chemistry
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Summary:Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompatibility, responsivity and displaying tunable chemical and mechanical properties. A complex scenario of molecular factors and conditions have to be taken into account to ensure the correct functionality of the bio-hydrogel as a scaffold or a delivery system, including the polymer backbone and biomolecule choice, polymerization conditions, architecture and biocompatibility. In this review, we present these key factors and conditions that have to match together to ensure the correct functionality of the bio-conjugated hydrogel. We then present recent examples of bio-conjugated hydrogel systems paving the way for regenerative medicine applications.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25184090