Exploring immune status in peripheral blood and tumor tissue in association with survival in patients with multi-organ metastatic colorectal cancer

Colorectal cancer (CRC) raises considerable clinical challenges, including a high mortality rate once the tumor spreads to distant sites. At this advanced stage, more accurate prediction of prognosis and treatment outcome is urgently needed. The role of cancer immunity in metastatic CRC (mCRC) is po...

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Bibliographic Details
Published in:Oncoimmunology 2024-12, Vol.13 (1), p.2361971
Main Authors: Bakkerus, Lotte, Subtil, Beatriz, Bontkes, Hetty J., Gootjes, Elske C., Reijm, Martine, Vullings, Manon, Verrijp, Kiek, Bokhorst, John-Melle, Woortman, Carmen, Nagtegaal, Iris D., Jonker, Marianne A., van der Vliet, Hans J., Verhoef, Cornelis, Gorris, Mark A.J., de Vries, I. Jolanda M., de Gruijl, Tanja D., Verheul, Henk M.W., Buffart, Tineke E., Tauriello, Daniele V. F.
Format: Article
Language:English
Subjects:
Adult
Aged
CD8-Positive T-Lymphocytes - immunology
Clinical-stage research
colorectal cancer
Colorectal Neoplasms - immunology
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Female
Humans
Liver Neoplasms - immunology
Liver Neoplasms - mortality
Liver Neoplasms - secondary
Lymphocytes, Tumor-Infiltrating - immunology
Male
metastasis
Middle Aged
Neoplasm Metastasis
Original Research
Prognosis
prognostic biomarkers
systemic immunity
tumour immune microenvironment
tumour immunity
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Summary:Colorectal cancer (CRC) raises considerable clinical challenges, including a high mortality rate once the tumor spreads to distant sites. At this advanced stage, more accurate prediction of prognosis and treatment outcome is urgently needed. The role of cancer immunity in metastatic CRC (mCRC) is poorly understood. Here, we explore cellular immune cell status in patients with multi-organ mCRC. We analyzed T cell infiltration in primary tumor sections, surveyed the lymphocytic landscape of liver metastases, and assessed circulating mononuclear immune cells. Besides asking whether immune cells are associated with survival at this stage of the disease, we investigated correlations between the different tissue types; as this could indicate a dominant immune phenotype. Taken together, our analyses corroborate previous observations that higher levels of CD8+ T lymphocytes link to better survival outcomes. Our findings therefore extend evidence from earlier stages of CRC to indicate an important role for cancer immunity in disease control even after metastatic spreading to multiple organs. This finding may help to improve predicting outcome of patients with mCRC and suggests a future role for immunotherapeutic strategies.
ISSN:2162-402X
2162-4011
2162-402X
DOI:10.1080/2162402X.2024.2361971