Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population

• Published in: BMC medical genetics 2019-07, Vol.20 (1), p.121-121, Article 121
• Main Authors: Chen, Xi, He, Xiang-Yu, Zhu, Chao, Zhang, Yusong, Li, Zongbin, Liu, Yuqi, Zhang, Yuxiao, Yin, Tong, Li, Yang
• Format: Article
• Language: English
• Subjects: Adult; Alleles; Asian Continental Ancestry Group - genetics; Blood Pressure; Essential Hypertension - genetics; Female; Genes; Genetic aspects; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Genetic susceptibility; Genetic Variation; Genotype; Humans; Hypertension; Interaction; Longevity - genetics; Male; Medical research; Middle Aged; Mitochondria; Mitochondria - genetics; NADH Dehydrogenase - genetics; NADH dehydrogenase subunit 2; Nicotinamide adenine dinucleotide; Odds Ratio; Risk Factors; Smoking - adverse effects; Triglycerides; Variation
• ISSN: 1471-2350; 1471-2350
• DOI: 10.1186/s12881-019-0838-3

The mitochondrial genotype 5178 cytosine/adenine (5178 C > A) within the NADH dehydrogenase subunit-2 gene (ND2) was proved to associate with longevity and predispose resistance to adult-onset diseases. This study aimed to confirm the interactive effects between ND 25178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese general population. The relationship between the ND2 5178 C > A variation and the risk of hypertension was investigated in 817 hypertensives and 821 matched normotensives. The interactive effects between ND2 5178 C > A and clinical risk factors were evaluated. The ND2 5178 A allele was more frequent in normotensives than in hypertensives (32.64% vs. 24.24%; adjusted OR: 0.62, 95% CI: 0.49-0.79, P = 1.3 × 10 ). After stratification, the significant association between ND2 5178 C > A and hypertension was found only in current smokers (OR: 0.44, 95% CI: 0.31-0.62), but not in non-current smokers (p