Positives and negatives of nonsteroidal anti-inflammatory drugs in bone healing: the effects of these drugs on bone repair

Tissue damage following injury triggers the processes of coagulation, inflammation and healing. In tissues surrounding the bone, the result of the healing process is a scar, while bone tissue has a unique ability to achieve shape, strength and pre-injury function. Bone healing is a process of regene...

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Bibliographic Details
Published in:Drug design, development and therapy development and therapy, 2018-01, Vol.12, p.1809-1814
Main Authors: Lisowska, Barbara, Kosson, Dariusz, Domaracka, Karolina
Format: Article
Language:English
Subjects:
Analgesics
Anesthesiology
Angiogenesis
Anti-inflammatory agents
Bone growth
Bone healing
Bones
Cell adhesion & migration
Coagulation
Cytokines
Drugs
Enzymes
Healing
Inflammation
Injury prevention
Intensive care
Musculoskeletal diseases
negative
Nonsteroidal anti-inflammatory drugs
NSAIDs
Pain
positive effect
Regeneration
Review
Rotator cuff
Time of use
Tissues
Trauma
Vascular endothelial growth factor
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Summary:Tissue damage following injury triggers the processes of coagulation, inflammation and healing. In tissues surrounding the bone, the result of the healing process is a scar, while bone tissue has a unique ability to achieve shape, strength and pre-injury function. Bone healing is a process of regeneration rather than classic recovery. The result of this process is the formation of new, healthy bone tissue instead of a scar. Many factors can inhibit or impair the bone healing process, and their influence is critical during the stages of inflammation and angiogenesis and finally on the clinical outcome. Nonsteroidal anti-inflammatory drugs (NSAIDs) play an essential role associated with their analgesic potency and anti-inflammatory effects. NSAIDs are also the most often used drugs in patients who require pain control and inflammation reduction due to musculoskeletal diseases or injures. Although their analgesic effect is well documented, NSAIDs also interfere with bone healing; therefore, the relative benefits and disadvantages connected with their administration should be taken into consideration. Despite the negative effect, NSAIDs have beneficial properties, but their clinical benefits in relation to dose and time of use are still unclear. Therefore, in this review, we focus on bone healing with relation to the impact of NSAIDs.
ISSN:1177-8881
1177-8881
DOI:10.2147/DDDT.S164565