The shape of things to come: structural insights into how prion proteins encipher heritable information

The prion hypothesis embodies the radical concept that prion proteins contain the necessary information for infectious replication within their shape, thus obviating the requirement for genomic material. Two elegant papers by Hoyt et al. and Manka et al. describing high-resolution structures of infe...

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Bibliographic Details
Published in:Nature communications 2022-07, Vol.13 (1), p.4003-3, Article 4003
Main Author: Telling, Glenn C.
Format: Article
Language:English
Subjects:
631/45/460
631/45/470/2284
631/45/535/1258/1259
Comment
Humanities and Social Sciences
Humans
Infections
multidisciplinary
Prion Diseases
Prion protein
Prion Proteins - genetics
Prions
Prions - metabolism
Proteins
Science
Science (multidisciplinary)
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Summary:The prion hypothesis embodies the radical concept that prion proteins contain the necessary information for infectious replication within their shape, thus obviating the requirement for genomic material. Two elegant papers by Hoyt et al. and Manka et al. describing high-resolution structures of infectious prions bring us closer to answering the long-standing question of how different prion conformations produce heritably distinct diseases.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-022-31460-8