The "SALPARE study" of spontaneous intracerebral haemorrhage-part 2-early CT predictors of outcome in ICH: keeping it simple

• Published in: Neurological research and practice 2023-01, Vol.5 (1), p.2-2, Article 2
• Main Authors: Manara, Renzo, De Rosa, Ludovica, Vodret, Francesca, Kulyk, Caterina, Pennella, Renato, Contrino, Eleonora, Cester, Giacomo, Causin, Francesco, Pieroni, Alessio, Viaro, Federica, Zedde, Maria Luisa, Pascarella, Rosario, Napoletano, Rosa, Baracchini, Claudio
• Format: Article
• Language: English
• Subjects: Cerebral hemorrhage; Clinical significance; Hematoma; Hematoma expansion; Hemorrhage; Multivariate analysis; NCCT markers
• ISSN: 2524-3489; 2524-3489
• DOI: 10.1186/s42466-022-00228-2

The aim of this study was to investigate the prognostic role of hematoma characteristics and hematoma expansion (HE) in patients with spontaneous intracerebral hemorrhage (ICH). This multicenter prospective cohort study enrolled consecutive adult patients with non-traumatic ICH admitted to three Italian academic hospitals (Salerno, Padova, Reggio Emilia) over a 2-year period. Early noncontrast CT (NCCT) features of the hematoma, including markers of HE, and 3-month outcome were recorded. Multivariable logistic regression analysis was performed to identify predictors of poor outcome. A total of 682 patients were included in the study [mean age: 73 ± 14 years; 316 (46.3%) females]. Pontine and massive hemorrhage, intraventricular bleeding, baseline hematoma volume > 15 mL, blend sign, swirl sign, margin irregularity ≥ 4, density heterogeneity ≥ 3, hypodensity ≥ 1, island sign, satellite sign, and black hole sign were associated with a higher risk of mortality and disability. However, at multivariate analysis only initial hematoma volume (OR 29.71) proved to be an independent predictor of poor functional outcome at 3 months. Simple hematoma volume measured on baseline CT best identifies patients with a worse outcome, while early NCCT markers of HE do not seem to add any clinically significant information.