Carbapenem-Resistant Klebsiella pneumoniae Associated with COVID-19

Infections with carbapenem-resistant are emerging as an important challenge in healthcare settings. Currently, carbapenem-resistant (CRKP) are the species of CRE most commonly encountered in hospitals. CRKP is resistant to almost all available antimicrobial agents, and infections with CRKP have been...

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Bibliographic Details
Published in:Antibiotics (Basel) 2021-05, Vol.10 (5), p.561
Main Authors: Dumitru, Irina Magdalena, Dumitrascu, Mirela, Vlad, Nicoleta Dorina, Cernat, Roxana Carmen, Ilie-Serban, Carmen, Hangan, Aurelia, Slujitoru, Raluca Elena, Gherghina, Aura, Mitroi-Maxim, Corina, Curtali, Licdan, Carp, Dalia Sorina, Dumitrescu, Anca, Mitan, Romelia, Lesanu, Rodica, Rugina, Sorin
Format: Article
Language:English
Subjects:
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacterial infections
carbapenem-resistant Klebsiella pneumoniae
Carbapenemase
Case Report
Ceftazidime
Coronaviruses
COVID-19
Hospitals
Infections
Intensive care units
Klebsiella
Klebsiella pneumoniae
KPC
Morbidity
Mortality
Patients
Viral diseases
Viral infections
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Summary:Infections with carbapenem-resistant are emerging as an important challenge in healthcare settings. Currently, carbapenem-resistant (CRKP) are the species of CRE most commonly encountered in hospitals. CRKP is resistant to almost all available antimicrobial agents, and infections with CRKP have been associated with high rates of morbidity and mortality, particularly among persons with prolonged hospitalization exposed to invasive devices. We report nine patients hospitalized in an intensive care unit (ICU) with severe coronavirus disease 2019 (COVID-19) who developed invasive infections due to carbapenemase-producing (CP-Kp), KPC and OXA-48, strains that have not been previously identified in our hospital. Despite ceftazidime/avibactam therapy, five patients died. Coinfections can contribute to a poor prognosis for patients with COVID-19, especially for high-risk populations such as elderly patients. Therefore, it is crucial to establish a rigorous program of antibiotic administration in intensive care units.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics10050561