Tubular atrophy/interstitial fibrosis scores of Oxford classification combinded with proteinuria level at biopsy provides earlier risk prediction in lgA nephropathy

The predictive effect of combining MEST with clinical data at biopsy on renal survival outcomes has not been investigated in patients with IgA nephropathy (IgAN). MEST of The Oxford classification of IgAN and 24-hour urine proteinuia measured at enrollment. The primary outcome was a composite of eit...

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Bibliographic Details
Published in:Scientific reports 2017-04, Vol.7 (1), p.1100-6, Article 1100
Main Authors: Zhu, Xuejing, Li, Huiqiong, Liu, Yexin, You, Jing, Qu, Zhong, Yuan, Shuguang, Peng, Youming, Liu, Fuyou, Liu, Hong
Format: Article
Language:English
Subjects:
14/63
692/4022/1585/104/1586
692/4022/1585/2759/1522
Atrophy
Atrophy - etiology
Atrophy - pathology
Biopsy
Decision Support Techniques
Epidermal growth factor receptors
Fibrosis
Fibrosis - etiology
Fibrosis - pathology
Follow-Up Studies
Glomerular Filtration Rate
Glomerulonephritis, IGA - diagnosis
Glomerulonephritis, IGA - mortality
Glomerulonephritis, IGA - pathology
Humanities and Social Sciences
Humans
IgA nephropathy
Immunoglobulin A
Kidneys
multidisciplinary
Prognosis
Proteinuria
Proteinuria - diagnosis
Proteinuria - etiology
Risk Assessment
Science
Science (multidisciplinary)
Survival
Survival Analysis
Urine
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Summary:The predictive effect of combining MEST with clinical data at biopsy on renal survival outcomes has not been investigated in patients with IgA nephropathy (IgAN). MEST of The Oxford classification of IgAN and 24-hour urine proteinuia measured at enrollment. The primary outcome was a composite of either ESRD (eGFR to 3 years, and were divided into two groups according to eGFR levels at biopsy. Multivariable logistical regression revealed that proteinuria at biopsy (OR 5.307 (95% Cl 3.003 to 9.376) p = 0.000), tubular atrophy/interstitial fibrosis scores (T) in MEST (OR 3.915 (95%Cl 2.710 to 5.654) p = 0.000) were the two predictors of eGFR decline for IgAN patients. Kaplan–Meier survival curves show significant difference in renal survival outcome among each T scores groups at biopsy (T0, T1, T2) (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-01223-3