Mechanisms of crosstalk between the oropharyngeal microbiome and human papillomavirus in oropharyngeal carcinogenesis: a mini review

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally. Notably, human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is on the rise, accounting for 70% of all OPSCC cases. Persistent high-risk HPV infection is linked to various cancers, b...

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Published in:Frontiers in oncology 2024-08, Vol.14, p.1425545
Main Authors: Chung, Ryan S, Wong, Stephanie, Lin, Dechen, Kokot, Niels C, Sinha, Uttam K, Han, Albert Y
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Language:English
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carcinogenesis
crosstalk
HPV
microbiome
Oncology
oropharyngeal cancer
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Wong, Stephanie
Lin, Dechen
Kokot, Niels C
Sinha, Uttam K
Han, Albert Y
description Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally. Notably, human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is on the rise, accounting for 70% of all OPSCC cases. Persistent high-risk HPV infection is linked to various cancers, but HPV infection alone is not sufficient to cause cancer. Advances in next-generation sequencing have improved our understanding of changes in the human microbiome of cancerous environments. Yet, there remains a dearth of knowledge on the impact of HPV-microbiome crosstalk in HPV-positive OPSCC. In this review, we examine what is known about the oropharyngeal microbiome and the compositional shifts in this microbiome in HPV-positive OPSCC. We also review potential mechanisms of crosstalk between HPV and specific microorganisms. Additional research is needed to understand these interactions and their roles on cancer development and progression.
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subjects carcinogenesis
crosstalk
HPV
microbiome
Oncology
oropharyngeal cancer
title Mechanisms of crosstalk between the oropharyngeal microbiome and human papillomavirus in oropharyngeal carcinogenesis: a mini review
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