Quality control of chondroitin sulphate used in dietary supplements

Chondroitin sulphate (CS), a complex polysaccharide isolated from animal cartilage, is used as an ingredient in dietary supplements to support joint health and/or to treat osteoarthritis. Several low-quality CS raw materials were identified in marketed products of dietary supplements. For the evalua...

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Bibliographic Details
Published in:Czech Journal of Food Sciences 2015-01, Vol.33 (2), p.165-173
Main Authors: VÁCLAVÍKOVÁ, Eliška, KVASNIČKA, František
Format: Article
Language:English
Subjects:
Biomedical materials
capillary isotachophoresis
Cartilage
Cartilage diseases
Citric acid
Diet
Dietary supplements
Electrolytes
electrophoresis
Glycine
Hydroxyethyl celluloses
Osteoarthritis
Polysaccharides
Quality control
Raw materials
Sulfates
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Summary:Chondroitin sulphate (CS), a complex polysaccharide isolated from animal cartilage, is used as an ingredient in dietary supplements to support joint health and/or to treat osteoarthritis. Several low-quality CS raw materials were identified in marketed products of dietary supplements. For the evaluation of the quality of CS, we present here a capillary isotachophoretic method (cITP). As a leading electrolyte for the anionic analysis of CS, a mixture of 5 mM HCl + 10 mM glycine + 0.01% of 2-hydroxyethylcellulose of pH 2.8 was used. A solution of 10 mM citric acid served as the terminating electrolyte. On a series of CS raw material samples we proved that the cITP is a suitable method for this purpose.
ISSN:1212-1800
1805-9317
DOI:10.17221/326/2014-CJFS