Quality control of chondroitin sulphate used in dietary supplements

Chondroitin sulphate (CS), a complex polysaccharide isolated from animal cartilage, is used as an ingredient in dietary supplements to support joint health and/or to treat osteoarthritis. Several low-quality CS raw materials were identified in marketed products of dietary supplements. For the evalua...

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Published in:Czech Journal of Food Sciences 2015-01, Vol.33 (2), p.165-173
Main Authors: VÁCLAVÍKOVÁ, Eliška, KVASNIČKA, František
Format: Article
Language:English
Subjects:
Biomedical materials
capillary isotachophoresis
Cartilage
Cartilage diseases
Citric acid
Diet
Dietary supplements
Electrolytes
electrophoresis
Glycine
Hydroxyethyl celluloses
Osteoarthritis
Polysaccharides
Quality control
Raw materials
Sulfates
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cited_by cdi_FETCH-LOGICAL-c373t-b0e943faca772f57c59735e1a930f3224c51cb58ba4d11f15a0f059b2dc5c9863
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container_title Czech Journal of Food Sciences
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description Chondroitin sulphate (CS), a complex polysaccharide isolated from animal cartilage, is used as an ingredient in dietary supplements to support joint health and/or to treat osteoarthritis. Several low-quality CS raw materials were identified in marketed products of dietary supplements. For the evaluation of the quality of CS, we present here a capillary isotachophoretic method (cITP). As a leading electrolyte for the anionic analysis of CS, a mixture of 5 mM HCl + 10 mM glycine + 0.01% of 2-hydroxyethylcellulose of pH 2.8 was used. A solution of 10 mM citric acid served as the terminating electrolyte. On a series of CS raw material samples we proved that the cITP is a suitable method for this purpose.
doi_str_mv 10.17221/326/2014-CJFS
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subjects Biomedical materials
capillary isotachophoresis
Cartilage
Cartilage diseases
Citric acid
Diet
Dietary supplements
Electrolytes
electrophoresis
Glycine
Hydroxyethyl celluloses
Osteoarthritis
Polysaccharides
Quality control
Raw materials
Sulfates
title Quality control of chondroitin sulphate used in dietary supplements
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