(‒)-Cannabidiolic Acid, a Still Overlooked Bioactive Compound: An Introductory Review and Preliminary Research

Cannabidiolic acid (CBDA) is the main phytocannabinoid in fiber and seed-oil hemp ( L.) plants, but its potential health-related capabilities have been masked for years by a greater scientific interest towards its neutral derivative cannabidiol (CBD). This review aims to collect from the literature...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-06, Vol.25 (11), p.2638
Main Authors: Formato, Marialuisa, Crescente, Giuseppina, Scognamiglio, Monica, Fiorentino, Antonio, Pecoraro, Maria Tommasina, Piccolella, Simona, Catauro, Michelina, Pacifico, Severina
Format: Article
Language:English
Subjects:
Acids
Adenosine
Anti-Inflammatory Agents - pharmacology
Anticarcinogenic Agents - pharmacology
Anticonvulsants
Anticonvulsants - pharmacology
Antiemetics - pharmacology
Antioxidants - pharmacology
Bioactive compounds
Biological activity
Biosynthesis
Brain research
Breast cancer
Cannabidiol
cannabidiolic acid
Cannabinoids
Cannabinoids - pharmacology
Cannabis
Cannabis - chemistry
Cannabis sativa L
Cell adhesion & migration
Cultivars
Enzymes
Hemp
hemp pollen
Inflammation
Leukemia
Marijuana
mass spectrometric techniques
Pollen
Review
Spectrometry
spectroscopic techniques
Tetrahydrocannabinol
THC
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cannabidiolic acid (CBDA) is the main phytocannabinoid in fiber and seed-oil hemp ( L.) plants, but its potential health-related capabilities have been masked for years by a greater scientific interest towards its neutral derivative cannabidiol (CBD). This review aims to collect from the literature and critically discuss all the information about this molecule, starting from its biosynthesis, and focusing on its bioactivity, as an anti-inflammatory, anti-emetic, anti-convulsant, and anti-cancerogenic drug. Furthermore, in the awareness that, despite its multiple bioactive effects, currently poor efforts have been made to achieve its reliable purification, herein, we propose a relatively simple, fast, and inexpensive procedure for its recovery from pollen of industrial hemp cultivars. Spectroscopic and spectrometric techniques allowed us to unequivocally identify pure isolated CBDA and to distinguish it from the constitutional isomer tetrahydrocannabinolic acid (THCA-A).
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25112638