EVALUATION OF AGREEMENT BETWEEN C/T-13910 POLYMORPHISM GENOTYPING RESULTS AND LACTOSE TOLERANCE TEST RESULTS: A RETROSPECTIVE POPULATION-BASED STUDY IN BRAZIL

Lactose tolerant test (LTT) is the most broadly used diagnostic test for lactose intolerance in Brazil, is an indirect, minimally invasive and a low-cost test that is widely available in primary care and useful in clinical practice. The C/T-13910 polymorphism in lactase persistence has been well cha...

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Bibliographic Details
Published in:Arquivos de gastroenterologia 2024, Vol.61, p.e23104
Main Authors: Cavichio, Marcia Wehba Esteves, Quaio, Caio Robledo D'Angioli Costa, Baratela, Wagner Antonio da Rosa, Oliveira, Patrícia Marinho Costa de, Tahan, Soraia
Format: Article
Language:English
Subjects:
Brazil
Child
Food intolerance
GASTROENTEROLOGY & HEPATOLOGY
genetic testing
Genotype
Humans
Lactase - genetics
lactose
Lactose Intolerance - diagnosis
Lactose Intolerance - genetics
Lactose Tolerance Test
Retrospective Studies
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Summary:Lactose tolerant test (LTT) is the most broadly used diagnostic test for lactose intolerance in Brazil, is an indirect, minimally invasive and a low-cost test that is widely available in primary care and useful in clinical practice. The C/T-13910 polymorphism in lactase persistence has been well characterized in Caucasian populations, but there are no studies evaluating the concordance between C/T-13910 polymorphism genotyping results and LTT results in Brazil, where the population is highly mixed. We aimed to evaluate agreement between presence of C/T-13910 polymorphism genotyping and malabsorption in LTT results. This is a retrospective analysis of a Brazilian population whose data were collected from a single laboratory database present in several Brazilian states. Results of individuals who underwent both genetic testing for lactose intolerance (C/T-13910 polymorphism genotyping) and an LTT from April 2016 until February 2019 were analysed to evaluate agreement between tests. Groups were classified according to age (
ISSN:0004-2803
1678-4219
1678-4219
DOI:10.1590/S0004-2803.24612023-104