Distinct patterns of serum and urine macrophage migration inhibitory factor kinetics predict death in sepsis: a prospective, observational clinical study

Macrophage migration inhibitory factor (MIF) has been considered as a biomarker in sepsis, however the predictive value of the pattern of its kinetics in the serum and in the urine has remained unclarified. It is also unclear whether the kinetics of MIF are different between males and females. We co...

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Bibliographic Details
Published in:Scientific reports 2023-01, Vol.13 (1), p.588-588, Article 588
Main Authors: Toldi, Janos, Kelava, Leonardo, Marton, Sandor, Muhl, Diana, Kustan, Peter, Feher, Zsolt, Maar, Klaudia, Garai, Janos, Pakai, Eszter, Garami, Andras
Format: Article
Language:English
Subjects:
631/250/256/1980
692/308/53/2422
692/308/53/2423
Adult
Biomarkers
Death
Female
Humanities and Social Sciences
Humans
Intensive Care Units
Kinetics
Leukocyte migration
Macrophage migration inhibitory factor
Macrophage Migration-Inhibitory Factors - blood
Macrophage Migration-Inhibitory Factors - chemistry
Macrophage Migration-Inhibitory Factors - urine
Male
Males
Mortality
multidisciplinary
Observational studies
Prospective Studies
Science
Science (multidisciplinary)
Sepsis
Sepsis - complications
Sepsis - diagnosis
Urine
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Summary:Macrophage migration inhibitory factor (MIF) has been considered as a biomarker in sepsis, however the predictive value of the pattern of its kinetics in the serum and in the urine has remained unclarified. It is also unclear whether the kinetics of MIF are different between males and females. We conducted a single-center prospective, observational study with repeated measurements of MIF in serum and urine on days 0, 2, and 4 from admission to the intensive care unit (ICU) in 50 adult septic patients. We found that in patients who died within 90 days, there was an increase in serum MIF level from day 0 to 4, whereas in the survivors there was rather a decrease ( p  = 0.018). The kinetics were sex-dependent as the same difference in the pattern was present in males ( p  = 0.014), but not in females ( p  = 0.418). We also found that urine MIF was markedly lower in patients who died than in survivors of sepsis ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-27506-6