Piper nigrum Fruit Extract as an Antibiotic Resistance Reversal Agent in MDR Bacteria

Antibiotic resistance development and spread in clinical pathogens is an immense threat that has already outpaced the discovery and development of novel and more effective antibiotic drugs. Recently the focus has been shifted to medicinal plants as novel therapeutic options for reversing antibiotic...

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Published in:Applied sciences 2022-12, Vol.12 (24), p.12542
Main Authors: Din, Maryam Salah Ud, Gohar, Umar Farooq, Hameed, Uzma, Mukhtar, Hamid, Morar, Adriana, Herman, Viorel, Imre, Kálmán
Format: Article
Language:English
Subjects:
Amikacin
Antibiotic resistance
antibiotic resistance reversal
Antibiotics
Antimicrobial agents
Bacteria
Clindamycin
Drug development
Drug resistance
Flavonoids
Gentamicin
Herbal medicine
Hospitals
Imipenem
Laboratories
Levofloxacin
Medicinal plants
multidrug-resistant bacteria
Oils & fats
Piper nigrum
Plasmids
Salmonella Typhi
Staphylococcus aureus
Tigecycline
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Summary:Antibiotic resistance development and spread in clinical pathogens is an immense threat that has already outpaced the discovery and development of novel and more effective antibiotic drugs. Recently the focus has been shifted to medicinal plants as novel therapeutic options for reversing antibiotic resistance by targeting different resistance mechanisms. Piper nigrum is a plant that has the potential to reverse antibiotic resistance and increase the efficacy of the current drugs. In the present study, seven different antibiotics, clindamycin, gentamicin, levofloxacin, amikacin, tigecycline, imipenem, and tetracycline, were used against antibiotic-resistant Staphylococcus aureus and Salmonella typhi. Antibiotic resistance reversal analysis was tested by the AST disc method. Increased zones of inhibition of S. aureus by four antibiotics, clindamycin (9 mm), gentamicin (7 mm), levofloxacin (9 mm), and amikacin (9 mm) were recorded after using P. nigrum extract. In addition, the use of P. nigrum extract also increased the zone of inhibition of S. typhi with amikacin (11 mm), gentamicin (10 mm), tigecycline (9 mm), levofloxacin (11 mm), and imipenem (10 mm). This study suggests that P. nigrum extracts can be used as natural antibiotic resistance reversal agents that increase the effectiveness of current antibiotics and can reverse antibiotic resistance.
ISSN:2076-3417
2076-3417
DOI:10.3390/app122412542