Primate-to-human retroviral transmission in Asia

We describe the first reported transmission to a human of simian foamy virus (SFV) from a free-ranging population of nonhuman primates in Asia. The transmission of an exogenous retrovirus, SFV, from macaques (Macaca fascicularis) to a human at a monkey temple in Bali, Indonesia, was investigated wit...

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Bibliographic Details
Published in:Emerging infectious diseases 2005-07, Vol.11 (7), p.1028-1035
Main Authors: Jones-Engel, Lisa, Engel, Gregory A, Schillaci, Michael A, Rompis, Aida, Putra, Artha, Suaryana, Komang Gde, Fuentes, Agustin, Beer, Brigitte, Hicks, Sarah, White, Robert, Wilson, Brenda, Allan, Jonathan S
Format: Article
Language:English
Subjects:
Adult
Animals
DNA, Viral - blood
exogenous retrovirus
Female
Humans
Indonesia - epidemiology
Keywords: Disease Transmission
Macaca
Macaca - virology
Macaca fascicularis
Macaca fascicularis - virology
Male
Middle Aged
Monkey Diseases - epidemiology
Monkey Diseases - transmission
Phylogeny
primate zoonoses
Retroviridae Infections - epidemiology
Retroviridae Infections - transmission
Retroviridae Infections - veterinary
Retrovirus
Retrovirus infections
Seroepidemiologic Studies
Simian foamy virus
Simian viruses
Southeast Asia
Spumavirus - genetics
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Summary:We describe the first reported transmission to a human of simian foamy virus (SFV) from a free-ranging population of nonhuman primates in Asia. The transmission of an exogenous retrovirus, SFV, from macaques (Macaca fascicularis) to a human at a monkey temple in Bali, Indonesia, was investigated with molecular and serologic techniques. Antibodies to SFV were detected by Western blotting of serum from 1 of 82 humans tested. SFV DNA was detected by nested polymerase chain reaction (PCR) from the blood of the same person. Cloning and sequencing of PCR products confirmed the virus's close phylogenetic relationship to SFV isolated from macaques at the same temple. This study raises concerns that persons who work at or live around monkey temples are at risk for infection with SFV.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1107.040957