PO.3.60 Association of left ventricular geometry abnormalities and disease activity in systemic lupus erythematosus patients

• Published in: Lupus science & medicine 2022-10, Vol.9 (Suppl 2), p.A58-A58
• Main Authors: Guajardo-Jauregui, N, Azpiri-Lopez, JR, Galarza-Delgado, DA, Colunga-Pedraza, IJ, Cardenas-De La Garza, JA, Lugo-Perez, S
• Format: Article
• Language: English
• Subjects: Geometry; Lupus; Thursday 06 October 2022 from 13:00 to 14:10; Ultrasonic imaging
• ISSN: 2053-8790
• DOI: 10.1136/lupus-2022-elm2022.90

PurposePatients with systemic lupus erythematosus (SLE) have higher risk of developing a cardiovascular event than the general population, with multiple factors contributing to this increased risk, including systemic inflammation. We aimed to compare the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and other disease characteristics of SLE patients with and without left ventricular (LV) geometry abnormalities.MethodsThis was a cross-sectional study nested of a SLE cohort. We recruited patients with SLE diagnosis according to the 2019 EULAR/ACR classification criteria, aged ≥ 18 years. A transthoracic echocardiogram was performed by two certified echocardiographers blinded to clinical information. Disease activity was assessed with SLEDAI. SLE patients with LV geometry abnormalities were included and matched by age and gender to SLE patients with normal LV geometry. Distribution was evaluated with the Kolmogorov-Smirnov test. Comparisons were performed with Chi-square or Fisher’s exact test for qualitative variables, and Student’s T-test or Mann-Whitney’s U-test for quantitative variables. A p-value < 0.05 was considered significant.ResultsA total of 44 SLE patients were included, 22 with LV geometry abnormalities and 22 with normal LV geometry. Mean age of SLE patients with LV geometry abnormalities was 35.1 ± 12.2 years, compared to 35.4 ± 9.4 years of SLE patients with normal LV geometry, p = 0.923. There were no significant differences inn demographic characteristics between both groups. Demographic characteristics are shown in Figure 1. We found that SLEDAI was significantly higher in SLE patients with LV geometry abnormalities (26.45 vs 17.33, p = 0.016). Comparisons of clinical characteristics between groups are shown in Table 1.Abstract PO.3.60 Table 1Comparison of disease characteristic of SLE patients with and without LV geometry abnormalitiesSLE, systemic lupus erythematosus; LV, left ventricular; NS, not significant; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; ANA, antinuclear antibodies; anti-dsDNA, anti-double stranded DNAAbstract PO.3.60 Figure 1Comparison of demographic characteristic of SLE patients with and without LV geometry abnormalitiesConclusionsSLE patients with LV geometry abnormalities had higher SLEDAI than patients with normal LV geometry. A transthoracic echocardiogram may be useful detect early cardiovascular abnormalities in SLE patie