Anti-photoaging effects of steam-exploded pine (Pinus densiflora) extract in ultraviolet B irradiation-damaged HaCaT keratinocytes

Ultraviolet B (UVB) irradiation causes photoaging, such as wrinkles, roughness and dryness of the skin, and it activates the production of reactive oxygen species (ROS) and inflammatory cytokines. In this study, the anti-photoaging activity of SEP-E (steam-exploded pine extract) was evaluated in HaC...

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Bibliographic Details
Published in:Bioresources 2024-08, Vol.19 (3), p.4423-4433
Main Authors: Jung, Ji Young, Yang, Si Young Ha, Yang, Jae-Kyung
Format: Article
Language:English
Subjects:
anti-photoaging
Antioxidants
Catalase
Cytokines
Cytotoxicity
Ethanol
Explosions
hacat keratinocytes
Inflammation
Interleukin 6
Interleukin 8
Interleukins
Irradiation
Keratinocytes
Monocyte chemoattractant protein
Monocyte chemoattractant protein 1
Monocytes
Oxidative stress
Phytochemicals
pinus densiflora
Polymerase chain reaction
Proteins
Radiation damage
Reactive oxygen species
Signal transduction
steam-explosion
Superoxide dismutase
Ultraviolet radiation
uvb
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Summary:Ultraviolet B (UVB) irradiation causes photoaging, such as wrinkles, roughness and dryness of the skin, and it activates the production of reactive oxygen species (ROS) and inflammatory cytokines. In this study, the anti-photoaging activity of SEP-E (steam-exploded pine extract) was evaluated in HaCaT keratinocytes damaged by UVB irradiation. SEP-E treatment showed cytoprotective effects in HaCaT keratinocytes irradiated with UVB (40 mJ/cm2). SEP-E treatment reduced ROS overproduction and promoted the expression of antioxidant enzymes, such as catalase, superoxide dismutase 1, and superoxide dismutase 2. Additionally, SEP-E treatment suppressed the expression of inflammatory cytokines, including interleukin 6, interleukin 8, and monocyte chemoattractant protein-1. Consequently, SEP-E shows potential as a natural material for photoaging treatment.
ISSN:1930-2126
1930-2126
DOI:10.15376/biores.19.3.4423-4433