Antimicrobial Activity and Cytotoxicity of Ag(I) and Au(I) Pillarplexes

The biological activity of four pillarplex compounds featuring different metals and anions was investigated. The toxicity of the compounds against four bacterial strains [ (ATCC6633), (ATCC6538), (UVI isolate), ], one fungus ( ), and a human cell line (HepG2) was determined. Additionally, a UV-Vis t...

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Bibliographic Details
Published in:Frontiers in chemistry 2018-11, Vol.6, p.584-584
Main Authors: Pöthig, Alexander, Ahmed, Sara, Winther-Larsen, Hanne Cecilie, Guan, Shengyang, Altmann, Philipp J, Kudermann, Jürgen, Santos Andresen, Adriana Magalhães, Gjøen, Tor, Høgmoen Åstrand, Ove Alexander
Format: Article
Language:English
Subjects:
antimicrobial
Chemistry
cytotoxicity
gold
NHC
organometallic
silver
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Summary:The biological activity of four pillarplex compounds featuring different metals and anions was investigated. The toxicity of the compounds against four bacterial strains [ (ATCC6633), (ATCC6538), (UVI isolate), ], one fungus ( ), and a human cell line (HepG2) was determined. Additionally, a UV-Vis titration study of the pillarplexes was carried out to check for stability depending on pH- and chloride concentration changes and evaluate the applicability in physiological media. All compounds are bioactive: the silver compounds showed higher activity against bacteria and fungi, and the corresponding gold pillarplexes were less toxic against human cells.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2018.00584