Assessment of high sensitivity C-reactive protein and coronary plaque characteristics by computed tomography in patients with and without diabetes mellitus

• Published in: BMC cardiovascular disorders 2020-10, Vol.20 (1), p.435-435, Article 435
• Main Authors: Zhou, Hai-Ting, Zhao, De-Li, Wang, Guo-Kun, Wang, Tian-Zuo, Liang, Hong-Wei, Zhang, Jin-Ling
• Format: Article
• Language: English
• Subjects: Adult; Aged; Angiography; Atherosclerosis; Atherosclerotic plaque; Biomarkers - blood; Body mass index; C-reactive protein; C-Reactive Protein - analysis; Calcification; Cardiovascular disease; Cholesterol; Complications and side effects; Computed tomography; Computed Tomography Angiography; Coronary Angiography; Coronary artery; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - epidemiology; Coronary heart disease; Coronary Stenosis - blood; Coronary Stenosis - diagnostic imaging; Coronary Stenosis - epidemiology; Coronary vessels; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Diabetes Mellitus - blood; Diabetes Mellitus - diagnosis; Diabetes Mellitus - epidemiology; Evaluation; Female; Glucose; Heart; Heart Disease Risk Factors; Heart diseases; High-sensitivity C-reactive protein test; Humans; Incidence; Lipoproteins; Male; Middle Aged; Multidetector Computed Tomography; Normal distribution; Patients; Plaque, Atherosclerotic; Plaques; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Assessment; Risk factors; Severity of Illness Index; Statistical analysis; Stenosis; Tomography; Up-Regulation; Vascular diseases; X-ray
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-020-01704-w

To evaluate the coronary plaque characteristics of coronary arteries using computed tomography angiography (CTA) in order to assess the risk of coronary artery disease and the relevance of high sensitivity C reactive protein (hs-CRP) in patients with Diabetes Mellitus (DM). The clinical data of 400 DM patients and 400 non-DM patients from January 2017 to December 2019 were collected, including the results of coronaryCTA. The plasma hs-CRP level of the two groups were divided into three groups: CRP ≤ 1, 1  2. The correlation of the degree of stenosis, the number of plaques, the nature of plaques and hs-CRP value between the two groups was evaluated. Compared with non-DM patients, the incidence of coronary artery plaques and lumen stenosis in DM patients was more higher than that in non-DM patients. DM patients were more likely to have more diseased vessels, especially diffuse vascular disease (12.00% vs 1.75%; P