Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

(also known as (L.) Urb. or Gotu kola) is a traditional Chinese medicine with extensive medicinal value, which is commonly used in Southeast Asian countries. This study aimed to summarize the effects of and its main components on neurological diseases, endocrine diseases, skin diseases, cardiovascul...

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Bibliographic Details
Published in:Frontiers in pharmacology 2020-09, Vol.11, p.568032
Main Authors: Sun, Boju, Wu, Lili, Wu, You, Zhang, Chengfei, Qin, Lingling, Hayashi, Misa, Kudo, Maya, Gao, Ming, Liu, Tonghua
Format: Article
Language:English
Subjects:
anti-apoptosis
anti-inflammatory
anti-oxidative stress
Centella asiatica
Pharmacology
triterpenoids
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Summary:(also known as (L.) Urb. or Gotu kola) is a traditional Chinese medicine with extensive medicinal value, which is commonly used in Southeast Asian countries. This study aimed to summarize the effects of and its main components on neurological diseases, endocrine diseases, skin diseases, cardiovascular diseases, gastrointestinal diseases, immune diseases, and gynecological diseases, as well as potential molecular mechanisms, to study the pathological mechanism of these diseases based on the changes at the molecular level. The results showed that and its triterpenoids had extensive beneficial effects on neurological and skin diseases, which were confirmed through clinical studies. They exhibited anti-inflammatory, anti-oxidative stress, anti-apoptotic effects, and improvement in mitochondrial function. However, further clinical studies are urgently required due to the low level of evidence and lack of patients.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2020.568032