Clinical value of detecting IQGAP3, B7-H4 and cyclooxygenase-2 in the diagnosis and prognostic evaluation of colorectal cancer

The IQ-motif-containing GTPase-activating protein (IQGAP) family comprises three members, IQGAP1, IQGAP2 and IQGAP3. IQGAP3 is the latest addition to the family. This study mainly investigated the novel marker IQGAP3 at serum and tumor tissue levels compared with the markers B7-H4 and cyclooxygenase...

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Published in:Cancer cell international 2019-06, Vol.19 (1), p.163-163, Article 163
Main Authors: Cao, Huihua, Wang, Qing, Gao, Zhenyan, Xu, Xiang, Lu, Qicheng, Wu, Yugang
Format: Article
Language:English
Subjects:
B7 antigen
B7-H4
Biomarkers
Colorectal cancer
Colorectal carcinoma
Cyclooxygenase-2
Diagnostic markers
Endoscopy
Enzyme-linked immunosorbent assay
GTPase-activating protein
Guanosine triphosphatases
Hospitals
Immunohistochemistry
IQ-motif-containing GTPase-activating protein
IQGAP1 protein
IQGAP3
Liver cancer
Medical prognosis
Metastasis
Mortality
Multivariate analysis
Primary Research
Risk factors
Serum levels
Tissues
Tumor markers
Tumors
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Summary:The IQ-motif-containing GTPase-activating protein (IQGAP) family comprises three members, IQGAP1, IQGAP2 and IQGAP3. IQGAP3 is the latest addition to the family. This study mainly investigated the novel marker IQGAP3 at serum and tumor tissue levels compared with the markers B7-H4 and cyclooxygenase-2 (COX-2) in patients with colorectal cancer (CRC) and in healthy individuals, aiming to evaluate the diagnostic and prognostic value of IQGAP3 for CRC. Serum samples were collected prior to any therapy in 118 CRC patients and as part of a routine examination in 85 healthy individuals. Serum IQGAP3, B7-H4 and COX-2 levels were measured using commercially available ELISA kits. Immunohistochemistry was performed to detect the IQGAP3, B7-H4 and COX-2 in tumor tissues and normal para-carcinoma tissues. The receiver operating characteristics (ROC) curve and the area under the curve (AUC) were used to evaluate and compare the diagnostic value of different serum tumor markers. Univariate and multivariate analyses were performed to identify the prognostic risk factors for CRC. IQGAP3, B7-H4 and COX-2 showed low or high expression in tumor tissues while no expression in normal para-carcinoma tissues. Serum levels of IQGAP3 in CRC group were significantly higher than those in healthy control group (  
ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-019-0881-3