SPINK5 is a Prognostic Biomarker Associated With the Progression and Prognosis of Laryngeal Squamous Cell Carcinoma Identified by Weighted Gene Co-Expression Network Analysis

Laryngeal squamous cell carcinoma (LSCC) is one of the most common types of head and neck squamous cell carcinomas (HNSCC) and is the second most prevalent malignancy occurring in the head and neck or respiratory tract, with a high incidence and mortality rate. Survival is limited for patients with...

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Published in:Evolutionary bioinformatics online 2022-02, Vol.18, p.11769343221077118-11769343221077118
Main Authors: Liu, Jian, Zhao, Jing, Xu, Jiaran, Sun, Qing, Qin, Xuemei, Chen, Guohui, Gao, Tianle, Bai, Guangping, Guo, Zhiqiang
Format: Article
Language:English
Subjects:
Basal cell carcinoma
Bioinformatics
Biomarkers
Cancer
DNA damage
DNA repair
Gene expression
Genes
Genomes
Head and neck carcinoma
Malignancy
Medical prognosis
Network analysis
Original Research
Prognosis
Protein interaction
Proteins
Respiratory tract
Squamous cell carcinoma
Survival
Survival analysis
Tumorigenesis
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Summary:Laryngeal squamous cell carcinoma (LSCC) is one of the most common types of head and neck squamous cell carcinomas (HNSCC) and is the second most prevalent malignancy occurring in the head and neck or respiratory tract, with a high incidence and mortality rate. Survival is limited for patients with LSCC. To identify more biomarkers associated with the prognosis of patients with LSCC, using bioinformatics analysis, this study used The Cancer Genome Atlas (TCGA) LSCC dataset and gene expression profiles of GSE59102 from the Gene Expression Omnibus (GEO). Eighty-one differentially co-expressed genes were identified by weighted gene co-expression network analysis (WGCNA). Next, 10 hub genes (PPL, KRT78, CRNN, PTK7, SCEL, AGRN, SPINK5, AIF1L, EMP1, and PPP1R3C) were screened from a protein-protein interaction (PPI) network. Based on survival analysis, SPINK5 was significantly correlated with survival time in LSCC patients. After verification in the TCGA and HPA databases, SPINK5 was selected as a prognostic biomarker. Finally, the GSEA results showed that downregulation of SPINK5 gene expression may promote tumorigenesis and the development of cancers by the “BASAL CELL CARCINOMA” pathway, and it has been implicated in disrupting DNA damage and repair pathways. Collectively, SPINK5 may serve as a potential prognostic biomarker in LSCC.
ISSN:1176-9343
1176-9343
DOI:10.1177/11769343221077118