Anti-Proliferative Effects of Iridoids from Valeriana fauriei on Cancer Stem Cells

We isolated seven new iridoid glucosides (valerianairidoids I-VII; - , , , , and ) and six known compounds from the methanol extract of the dried rhizomes and roots of . Chemical and spectroscopic data were used to elucidate the chemical structures of the seven new iridoid glucosides, and their abso...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-11, Vol.23 (22), p.14206
Main Authors: Yoshikawa, Hayato, Matsumoto, Takahiro, Kitagawa, Takahiro, Okayama, Masaya, Ohta, Tomoe, Yoshida, Tatsusada, Watanabe, Tetsushi
Format: Article
Language:English
Subjects:
Aglycones
Antiproliferatives
Brain cancer
Breast cancer
cancer prevention
cancer stem cell
Cancer therapies
cancer treatment
Chromatography
Circular dichroism
Dichroism
ECD
Glucose
Glucosides
Humans
Iridoid Glucosides - pharmacology
Iridoids - chemistry
Neoplasms
Neoplastic Stem Cells
NMR
Nuclear magnetic resonance
Plant Roots
Rhizomes
Stem cells
Valerian
Valeriana fauriei
valerianairidoid
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Summary:We isolated seven new iridoid glucosides (valerianairidoids I-VII; - , , , , and ) and six known compounds from the methanol extract of the dried rhizomes and roots of . Chemical and spectroscopic data were used to elucidate the chemical structures of the seven new iridoid glucosides, and their absolute configurations were determined by comparing their electronic circular dichroism (ECD) spectra with those determined experimentally. Aglycones , , and , which were obtained by enzymatic hydrolysis of the isolated iridoid glucosides, exhibited anti-proliferative activities against cancer stem cells (CSCs) established by a sphere-formation assay using human breast cancer (MDA-MB-231) and human astrocytoma (U-251MG) cells. Interestingly, these iridoids selectively showed anti-proliferative activities against CSCs from MDA-MB-231 cells. These results suggest that the iridoids obtained in this study may have potency as a breast cancer treatment and as preventive agent via exterminating CSCs.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232214206