Comprehensive assessment of coronary pulse wave velocity in anesthetized pigs

Background Coronary stiffness represents a new paradigm for interventional cardiology and can be assessed by coronary pulse wave velocity (CoPWV). Assessing CoPWV is complex because of the coexistence of backward and forward waves. Objectives Evaluate the feasibility, repeatability, and capacity of...

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Bibliographic Details
Published in:Physiological reports 2020-05, Vol.8 (9), p.e14424-n/a
Main Authors: Cividjian, Andrei, Harbaoui, Brahim, Chambonnet, Carole, Bonnet, Jeanne‐Marie, Paquet, Christian, Courand, Pierre‐Yves, Lantelme, Pierre
Format: Article
Language:English
Subjects:
Anesthesia
Animals
Arterial Pressure
Balloon treatment
Blood Flow Velocity
Blood Pressure
Blood Pressure Determination - methods
Cardiovascular Conditions, Disorders and Treatments
Cardiovascular disease
Coexistence
Coronary Circulation - physiology
coronary physiology
coronary stiffness
Coronary vessels
Coronary Vessels - physiology
Female
Heart
Heart Rate
Human health and pathology
Implants
Life Sciences
Methods
Models, Animal
Original Research
Physiology
Pulsatile Flow
Pulse Wave Analysis - methods
pulse wave velocity
Sensors
Software
Swine
Velocity
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Summary:Background Coronary stiffness represents a new paradigm for interventional cardiology and can be assessed by coronary pulse wave velocity (CoPWV). Assessing CoPWV is complex because of the coexistence of backward and forward waves. Objectives Evaluate the feasibility, repeatability, and capacity of methods assessing CoPWV to detect predictable velocity changes. Methods CoPWV was measured from distal and proximal pressure guidewires in the left anterior descending artery of 10 pigs under general anesthesia. Four methods were studied: the tangent intersection method applied to the forward (FW) and backward (BK) waves, as well as the dicrotic notch (DIC) and template matching (TM) methods. All were evaluated at baseline, during various arterial pressure and heart rate conditions, during simulated flow limitation (balloon inflation), and after increasing coronary stiffness (stent insertion). Results All the methods were significantly different between them (p ≤ .05) showing a systematic trend toward higher CoPWV when compared to the FW method (.05 
ISSN:2051-817X
2051-817X
DOI:10.14814/phy2.14424